Synthesis of novel 6-unsubstituted 2-aminodihydropyrimidines by Sc(OTf)3-mediated amination and their antiproliferative effect on HL-60 cells
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DOI: 10.1016/j.tetlet.2020.152760
Abstract: Abstract An efficient method of synthesis of novel 6-unsubstituted 2-aminodihydropyrimidines 9 has been developed. The substitution reaction of 2-methylthiodihydropyrimidines 7 and primary amines in the presence of a catalytic amount of Sc(OTf)3 with heating proceeds… read more here.
Keywords: antiproliferative effect; aminodihydropyrimidines otf; novel unsubstituted; synthesis novel ... See more keywords