Novel venom‐derived inhibitors of the human EAG channel, a putative antiepileptic drug target
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.08.038
Abstract: &NA; Recently, we and other groups revealed that gain‐of‐function mutations in the human ether à go‐go voltage‐gated potassium channel hEAG1 (Kv10.1) lead to developmental disorders with associated infantile‐onset epilepsy. However, the physiological role of hEAG1… read more here.
Keywords: derived inhibitors; human eag; inhibitors human; channel ... See more keywords
A Segregating Structural Variant Defines Novel Venom Phenotypes in the Eastern Diamondback Rattlesnake
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msaf058
Abstract: Abstract Of all mutational mechanisms contributing to phenotypic variation, structural variants are both among the most capable of causing major effects as well as the most technically challenging to identify. Intraspecific variation in snake venoms… read more here.
Keywords: novel venom; venom phenotypes; variation; eastern diamondback ... See more keywords