A novel 3D in vitro model of glioblastoma reveals resistance to temozolomide which was potentiated by hypoxia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03107-0
Abstract: PurposeGlioblastoma (GBM) is the most common invasive malignant brain tumour in adults. It is traditionally investigated in vitro by culturing cells as a monolayer (2D culture) or as neurospheres (clusters enriched in cancer stem cells)… read more here.
Keywords: vitro model; novel vitro; model glioblastoma; model ... See more keywords
Development of a novel in vitro 3D intestinal model for permeability evaluations
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Food Sciences and Nutrition"
DOI: 10.1080/09637486.2019.1700940
Abstract: Abstract In this work, a new three-dimensional (3D) in vitro cell model was described, which was comprised of an epithelium, a subepithelial fibroblast network and an extracellular matrix, thereby more closely mimicking the morphology of… read more here.
Keywords: intestinal model; novel vitro; vitro intestinal; permeability ... See more keywords
MarioHeart: Novel In-Vitro Flow Model for Testing Heart Valve Prostheses and Anticoagulant Therapies
Sign Up to like & getrecommendations! Published in 2023 at "ASAIO Journal"
DOI: 10.1097/mat.0000000000001915
Abstract: Mechanical heart valve (MHV) prostheses present a risk of thromboembolic complications despite antithrombotic therapy. Further steps in the development of more hemocompatible MHVs and new anticoagulants are impeded due to the lack of adequate in-vitro… read more here.
Keywords: vitro; novel vitro; flow; heart valve ... See more keywords
A novel in vitro model for haematogenous spreading of S. aureus device biofilms demonstrating clumping dispersal as an advantageous dissemination mechanism
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DOI: 10.1111/cmi.12785
Abstract: Staphylococcus aureus is able to disseminate from vascular device biofilms to the blood and organs, resulting in life‐threatening infections such as endocarditis. The mechanisms behind spreading are largely unknown, especially how the bacterium escapes immune… read more here.
Keywords: clumping dispersal; model; device biofilms; novel vitro ... See more keywords
New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00556-22
Abstract: The development and spread of drug-resistant phenotypes substantially threaten malaria control efforts. Combination therapies have the potential to minimize the risk of resistance development but require intensive preclinical studies to determine optimal combination and dosing… read more here.
Keywords: development; novel vitro; combination; clinical development ... See more keywords
Novel In Vitro Cancer Models for Optimizing Anti-EGFR Therapies
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-2937
Abstract: Preclinical models, which are able to recapitulate the biology and pathology of the original individual cancer, are needed to better investigate mechanisms of response and resistance to anticancer therapies. In this respect, novel in vitro… read more here.
Keywords: novel vitro; vitro cancer; optimizing anti; cancer ... See more keywords
Abstract 5338: A novel in vitro assay to evaluate the roles of hepatic metabolism on anticancer drug safety and efficacy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5338
Abstract: It has been well-established that hepatic drug metabolism may have significant impact on the efficacy and off-target toxicity of anticancer drugs. We present here an in vitro assay, the metabolism-dependent cytotoxicity assay (MDCA), for the… read more here.
Keywords: metabolism; human hepatocytes; vitro assay; novel vitro ... See more keywords
Recent progresses in novel in vitro models of primary neurons: A biomaterial perspective
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.953031
Abstract: Central nervous system (CNS) diseases have been a growing threat to the health of humanity, emphasizing the urgent need of exploring the pathogenesis and therapeutic approaches of various CNS diseases. Primary neurons are directly obtained… read more here.
Keywords: culture; vitro models; primary neurons; novel vitro ... See more keywords
Kinase Inhibitors with Antiepileptic Properties Identified with a Novel in Vitro Screening Platform
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20102502
Abstract: Kinase signaling plays an important role in acquired epilepsy, but only a small percentage of the total kinome has been investigated in this context. A major roadblock that prevents the systematic investigation of the contributions… read more here.
Keywords: kinase inhibitors; novel vitro; antiepileptic properties; platform ... See more keywords
Hemorrhagic Cerebral Insults and Secondary Takotsubo Syndrome: Findings in a Novel In Vitro Model Using Human Blood Samples
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911557
Abstract: Intracranial hemorrhage results in devastating forms of cerebral damage. Frequently, these results also present with cardiac dysfunction ranging from ECG changes to Takotsubo syndrome (TTS). This suggests that intracranial bleeding due to subarachnoid hemorrhage (SAH)… read more here.
Keywords: takotsubo syndrome; novel vitro; tts; vitro model ... See more keywords