Catalytic Generation of Remote C-N Axial Chirality through Atroposelective de novo Arene Construction.
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DOI: 10.1021/acs.orglett.2c03272
Abstract: The first atroposelective desymmetrization of prochiral N-aryl maleimides through its conversion to axially chiral phthalimides is developed by applying a de novo arene construction strategy. Catalyzed by bis(3,5-dimethylphenyl)prolinol TMS-ether, this reaction proceeds through oxidative [4… read more here.
Keywords: catalytic generation; novo arene; arene construction; generation remote ... See more keywords