Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
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DOI: 10.1038/s41467-020-19878-4
Abstract: Senescence is a state of stable proliferative arrest, generally accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin loops, play a key role in gene regulation but their relevance… read more here.
Keywords: chromatin loops; novo cohesin; cohesin; senescence ... See more keywords