De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07937
Abstract: Bioengineering of ribosomally synthesized and post-translationally modified peptides (RiPPs) is an emerging approach to explore the diversity of pseudo-natural product structures for drug discovery purposes. However, despite the initial advances in this area, bioactivity reprogramming… read more here.
Keywords: novo discovery; natural products; pseudo natural; kinase ... See more keywords
Genotyping and de novo discovery of allelic variants at the Brassicaceae self-incompatibility locus from short read sequencing data.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msz258
Abstract: Plant self-incompatibility (SI) is a genetic system that prevents selfing and enforces outcrossing. Because of strong balancing selection, the genes encoding SI are predicted to maintain extraordinarily high levels of polymorphism, both in terms of… read more here.
Keywords: novo discovery; discovery allelic; genotyping novo; database ... See more keywords
Methodologies for the De novo Discovery of Transposable Element Families
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DOI: 10.3390/genes13040709
Abstract: The discovery and characterization of transposable element (TE) families are crucial tasks in the process of genome annotation. Careful curation of TE libraries for each organism is necessary as each has been exposed to a… read more here.
Keywords: methodologies novo; novo discovery; element families; discovery transposable ... See more keywords