Single-Atom-Directed Inhibition of De Novo DNA Synthesis in Isothermal Amplifications.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03489
Abstract: The template-dependent DNA synthesis, with DNA polymerases, templates, and primers, is essential for disease detection, molecular biology, and biotechnology. However, DNA polymerases can also initiate de novo DNA synthesis without templates and primers, forming byproduct… read more here.
Keywords: dna; atom; novo dna; synthesis ... See more keywords
Missing for partnership: understanding nucleosomal de novo DNA cytosine methylation by a spliced DNMT3 complex
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00461-2
Abstract: In a recent paper published in Nature, Xu et al. present a cryo-EM structure of a ‘spliced’ de novo DNA methyltransferase complex, DNMT3A2-DNMT3B3, bound to a mono-nucleosome with extended linker DNA. Reinforced by biochemical assays… read more here.
Keywords: methylation; dna; linker dna; novo dna ... See more keywords
Ovarian hormones induce de novo DNA methyltransferase expression in the Siberian hamster suprachiasmatic nucleus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12819
Abstract: The present study investigated neuroanatomically localised changes in de novo DNA methyltransferase expression in the female Siberian hamster (Phodopus sungorus). The objectives were to identify the neuroendocrine substrates that exhibit rhythmic Dnmt3a and Dnmt3b expression… read more here.
Keywords: novo dna; expression; suprachiasmatic nucleus; dna methyltransferase ... See more keywords