Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.
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DOI: 10.1016/j.cmet.2018.06.003
Abstract: The enzyme glutaminase (GLS1) is currently in clinical trials for oncology, yet there are no clear diagnostic criteria to identify responders. The evaluation of 25 basal breast lines expressing GLS1, predominantly through its splice isoform… read more here.
Keywords: pan cancer; cancer metabolic; novo glutathione; glutathione synthesis ... See more keywords