HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
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DOI: 10.1371/journal.ppat.1006658
Abstract: Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional DNA replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) and sulfamoylbenzamides (SBAs),… read more here.
Keywords: protein; core protein; novo infection; dna ... See more keywords
PRC1-independent binding and activity of RYBP on the KSHV genome during de novo infection
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010801
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes lifelong infection in humans by establishing latency after primary infection. Latent infection is a prerequisite for both persistent infection and the development of KSHV-associated cancers.… read more here.
Keywords: infection; lytic genes; prc1 independent; novo infection ... See more keywords