Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models
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DOI: 10.1126/scitranslmed.abq6288
Abstract: Deregulated de novo lipid synthesis (DNLS) is a potential druggable vulnerability in glioblastoma (GBM), a highly lethal and incurable cancer. Yet the molecular mechanisms that determine susceptibility to DNLS-targeted therapies remain unknown, and the lack… read more here.
Keywords: lipid synthesis; novo lipid; gbm; lipotoxicity ... See more keywords