Blood meal drives de novo lipogenesis in the fat body of Rhodnius prolixus.
Sign Up to like & getrecommendations! Published in 2020 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2020.103511
Abstract: In insects, lipids are stored in the fat body mainly as triacylglycerol. Lipids can be directly provided by digestion and incorporated from the hemolymph, or synthesized de novo from other substrates such as carbohydrates and… read more here.
Keywords: novo lipogenesis; fat body; body; blood meal ... See more keywords
Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2017.02.008
Abstract: Abstract Metabolically beneficial effects of decursin and decursinol angelate have been reported. However, it is unclear whether Angelica gigas Nakai extract (AGNE), which is rich in decursin and decursinol angelate, can alleviate high-fat diet (HFD)-mediated… read more here.
Keywords: novo lipogenesis; decursinol angelate; decursin decursinol;
MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.09.011
Abstract: Physical contact between organelles is vital to the function of eukaryotic cells. Lipid droplets (LDs) are dynamic organelles specialized in lipid storage that interact physically with mitochondria in several cell types. The mechanisms coupling these… read more here.
Keywords: novo lipogenesis; links mitochondria; lipid droplets; miga2 links ... See more keywords
CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101428
Abstract: Objective Enhanced de novo lipogenesis (DNL) in hepatocytes is a major contributor to nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase (FAT/CD36) is involved in the pathogenesis of NAFLD through facilitating free fatty acids uptake.… read more here.
Keywords: srebp1 processing; novo lipogenesis; cd36; cd36lko mice ... See more keywords
Adipose-Specific Knockout of Protein Kinase D1 Suppresses de novo Lipogenesis in Mice via SREBP1c-dependent Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112548
Abstract: Having healthy adipose tissue is essential for metabolic health, as excessive adipose tissue in the body can cause its dysregulation and driving chronic metabolic diseases. Protein kinase D1 (PKD1) is considered to be a key… read more here.
Keywords: pkd1; novo lipogenesis; lipogenesis; adipose tissue ... See more keywords
HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Nature genetics"
DOI: 10.1038/s41588-022-01045-8
Abstract: HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR) activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in AR-independent contexts remain elusive. Here we report HOXB13 interaction with histone deacetylase HDAC3, which… read more here.
Keywords: hoxb13; novo lipogenesis; pca; prostate cancer ... See more keywords
Interaction effect between NAFLD severity and high carbohydrate diet on gut microbiome alteration and hepatic de novo lipogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2078612
Abstract: ABSTRACT Nonalcoholic fatty liver disease (NAFLD) is associated with high carbohydrate (HC) intake. We investigated whether the relationship between carbohydrate intake and NAFLD is mediated by interactions between gut microbial modulation, impaired insulin response, and… read more here.
Keywords: gut microbiome; high carbohydrate; carbohydrate; hepatic novo ... See more keywords
Celecoxib attenuates hepatosteatosis by impairing de novo lipogenesis via Akt‐dependent lipogenic pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17435
Abstract: Mounting evidence indicates that hepatic de novo lipogenesis is a common abnormality in non‐alcoholic fatty liver disease (NAFLD) patients. We investigated whether a selective COX‐2 inhibitor, celecoxib, alleviates hepatic steatosis by targeting an Akt‐driven lipogenic… read more here.
Keywords: celecoxib; lipogenic pathway; novo lipogenesis; lipogenesis ... See more keywords
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aau8465
Abstract: De novo lipogenesis is essential for human sebum production, and increased lipogenic flux accounts for excessive sebum production in acne vulgaris. Getting the skinny on sebum Sebum, an oily material secreted by glands in the… read more here.
Keywords: novo lipogenesis; sebum production; acne vulgaris; sebum ... See more keywords
Impact of sustained de novo lipogenesis on mitochondrial dysfunction and hepatocellular redox during fatty liver disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730204
Abstract: Dysfunctional mitochondrial metabolism and sustained de novo lipogenesis are characteristic of non-alcoholic fatty liver disease (NAFLD), a common comorbidity of obesity and type 2 diabetes. We hypothesize that sustained de novo lipogenesis, through its biochemical… read more here.
Keywords: physiology; novo lipogenesis; lipogenesis; tca cycle ... See more keywords
Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Medicine"
DOI: 10.1371/journal.pmed.1003102
Abstract: Background De novo lipogenesis (DNL) is the primary metabolic pathway synthesizing fatty acids from carbohydrates, protein, or alcohol. Our aim was to examine associations of in vivo levels of selected fatty acids (16:0, 16:1n7, 18:0,… read more here.
Keywords: incidence type; novo lipogenesis; fatty acids; cohort ... See more keywords