Reshaping de Novo Protein Switches into Bioresponsive Materials for Biomarker, Toxin, and Viral Detection
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202208556
Abstract: De novo designed protein switches are powerful tools to specifically and sensitively detect diverse targets with simple chemiluminescent readouts. Finding an appropriate material host for de novo designed protein switches without altering their thermodynamics while… read more here.
Keywords: switches bioresponsive; reshaping novo; detection; novo protein ... See more keywords
Hyperstable De Novo Protein with a Dimeric Bisecting Topology.
Sign Up to like & getrecommendations! Published in 2020 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.9b00501
Abstract: Recently, we designed and assembled protein nanobuilding blocks (PN-Blocks) from an intermolecularly folded dimeric de novo pro-tein called WA20. Using this dimeric 4-helix bundle, we construct-ed a series of self-assembling supramolecular nanostructures in-cluding polyhedra and… read more here.
Keywords: protein; wa20; bisecting topology; topology ... See more keywords
Sequential search leads to faster, more efficient fragment-based de novo protein structure prediction
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx722
Abstract: Abstract Motivation Most current de novo structure prediction methods randomly sample protein conformations and thus require large amounts of computational resource. Here, we consider a sequential sampling strategy, building on ideas from recent experimental work… read more here.
Keywords: protein structure; prediction; structure prediction; novo protein ... See more keywords
A generic framework for hierarchical de novo protein design
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.04.07.487481
Abstract: De novo protein design enables the exploration of novel sequences and structures absent from the natural protein universe. De novo design also stands as a stringent test to our understanding of the underlying physical principles… read more here.
Keywords: protein design; framework; design; novo protein ... See more keywords
Fact or fiction: updates on how protein-coding genes might emerge de novo from previously non-coding DNA
Sign Up to like & getrecommendations! Published in 2017 at "F1000Research"
DOI: 10.12688/f1000research.10079.1
Abstract: Over the last few years, there has been an increasing amount of evidence for the de novo emergence of protein-coding genes, i.e. out of non-coding DNA. Here, we review the current literature and summarize the… read more here.
Keywords: coding dna; non coding; novo protein; protein coding ... See more keywords