NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.09.010
Abstract: Nuclear factor erythroid-2 related factor 2 (NRF2) is a pivotal transcription factor; that maintains cellular redox homeostasis and facilitates the development of; malignant tumor phenotypes. At the molecular level, NRF2 promotes de novo serine; synthesis… read more here.
Keywords: sumoylation; tumorigenesis; serine synthesis; nrf2 sumoylation ... See more keywords
3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo l-Serine Synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00990
Abstract: The enzymatic mechanism of 3-phosphoglycerate to 3-phosphohydroxypyruvate oxidation, which forms the first step of the main conserved de novo serine synthesis pathway, has been revisited recently in certain microorganisms. While this step is classically considered… read more here.
Keywords: phosphoglycerate; serine synthesis; yeast; novo serine ... See more keywords
Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00474-4
Abstract: To sustain their malignancy, tumour cells acquire several metabolic adaptations such as increased oxygen, glucose, glutamine, and lipids uptake. Other metabolic processes are also enhanced as part of tumour metabolic reprogramming, for example, increased serine… read more here.
Keywords: serine synthesis; small molecular; novo serine; cancer ... See more keywords
Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28272-1
Abstract: Sustained mitochondrial fitness relies on coordinated biogenesis and clearance. Both processes are regulated by constant targeting of proteins into the organelle. Thus, mitochondrial protein import sets the pace for mitochondrial abundance and function. However, our… read more here.
Keywords: mitochondrial protein; novo serine; serine biosynthesis; protein import ... See more keywords