Systematic Metabolic Profiling Identifies De Novo Sphingolipid Synthesis as Hypha Associated and Essential for Candida albicans Filamentation
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DOI: 10.1128/msystems.00539-22
Abstract: The reversible switch of Candida albicans between unicellular yeast and multicellular hyphal growth is accompanied by a well-studied hypha-associated gene expression, encoding virulence factors like adhesins, toxins, or nutrient scavengers. The investigation of this gene… read more here.
Keywords: hypha; hypha associated; novo sphingolipid; gene expression ... See more keywords
Sphingosine kinase and sphingosine-1-phosphate regulate epithelial cell architecture by the modulation of de novo sphingolipid synthesis
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DOI: 10.1371/journal.pone.0213917
Abstract: Sphingolipids regulate several aspects of cell behavior and it has been demonstrated that cells adjust their sphingolipid metabolism in response to metabolic needs. Particularly, sphingosine-1-phosphate (S1P), a final product of sphingolipid metabolism, is a potent… read more here.
Keywords: sphingolipid synthesis; novo sphingolipid; sphingosine; sphingosine phosphate ... See more keywords