p67phox binds to a newly identified site in Nox2 following the disengagement of an intramolecular bond—Canaan sighted?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a1219-607r
Abstract: Activation of the phagocyte NADPH oxidase involves a conformational change in Nox2. The effector in this process is p67phox and there is evidence for a change in the configuration of p67phox being required for binding… read more here.
Keywords: intramolecular bond; nox2; site; p67phox ... See more keywords
Down‐regulation of NOX2 activity in phagocytes mediated by ATM‐kinase dependent phosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.09.007
Abstract: Abstract NADPH oxidases (NOX) have many biological roles, but their regulation to control production of potentially toxic ROS molecules remains unclear. A previously identified insertion sequence of 21 residues (called NIS) influences NOX activity, and… read more here.
Keywords: nox2; activity; atm kinase; phosphorylation ... See more keywords
Nox2+ Myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1.
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DOI: 10.1093/cvr/cvaa042
Abstract: AIMS Heart failure (HF) ensuing myocardial infarction (MI) is characterized by the initiation of a systemic inflammatory response. We aimed to elucidate the impact of myelomonocytic cells and their activation by angiotensin II on vascular… read more here.
Keywords: myeloid cells; receptor; myeloid; endothelial dysfunction ... See more keywords
Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells
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DOI: 10.3389/fcimb.2017.00291
Abstract: Porphyromonas gingivalis, a major opportunistic pathogen in the etiology of chronic periodontitis, successfully survives in human gingival epithelial cells (GECs). P. gingivalis abrogates the effects of a host danger molecule, extracellular ATP (eATP)/P2X7 signaling, such… read more here.
Keywords: epithelial cells; infection; porphyromonas gingivalis; gingivalis ... See more keywords