NOX2 NADPH oxidase controls responses to infection and sterile inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.092
Abstract: The NOX2 NADPH oxidase generates superoxide following activation by microbial or other inflammatory stimuli. Inactivating mutations in this leukocyte enzyme result in chronic granulomatous disease (CGD), a primary immunodeficiency associated with recurrent bacterial and fungal… read more here.
Keywords: oxidase; nox2 nadph; sterile inflammation; nadph oxidase ... See more keywords
Downregulation of PPARĪ± during Experimental Left Ventricular Hypertrophy is Critically Dependent on Nox2 NADPH Oxidase Signalling
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21124406
Abstract: Pressure overload-induced left ventricular hypertrophy (LVH) is initially adaptive but ultimately promotes systolic dysfunction and chronic heart failure. Whilst underlying pathways are incompletely understood, increased reactive oxygen species generation from Nox2 NADPH oxidases, and metabolic… read more here.
Keywords: ppar; nox2 nadph; ventricular hypertrophy; downregulation ... See more keywords