Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways
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DOI: 10.1007/s00395-020-00834-8
Abstract: Chronic hyperglycemia and diabetes lead to impaired cardiac repolarization, K+ channel remodeling and increased arrhythmia risk. However, the exact signaling mechanism by which diabetic hyperglycemia regulates cardiac K+ channels remains elusive. Here, we show that… read more here.
Keywords: nox2 ros; hyperglycemia regulates; camkii; hyperglycemia ... See more keywords
Mechanism of miR-320 in Regulating Biological Characteristics of Ischemic Cerebral Neuron by Mediating Nox2/ROS Pathway
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DOI: 10.1007/s12031-019-01434-5
Abstract: This study aimed to explore the mechanism of miR-320 in regulating biological characteristics of ischemic cerebral neuron by mediating Nox2/ROS pathway. Primary neurons were cultured and grouped: normal group (normal primary neurons), negative control (NC)… read more here.
Keywords: nox2 ros; primary neurons; group; ischemic cerebral ... See more keywords
Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling
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DOI: 10.1016/j.ebiom.2019.08.057
Abstract: Background Cisplatin resistance remains a major clinical obstacle to the successful treatment of non-small cell lung cancer (NSCLC). Scribble contributes to ROS-induced inflammation and cisplatin-elevated toxic reactive oxygen species (ROS) promotes cell death. However, it… read more here.
Keywords: chemotherapy; nox2 ros; cisplatin; ros nrf2 ... See more keywords
Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy
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DOI: 10.1128/mbio.02148-19
Abstract: Our previous reports showed that the LC3-associated GAS-containing single membrane vacuoles are inefficient for bacterial clearance in endothelial cells, which may result in bacteremia. However, the characteristics and the induction mechanisms of these LC3-positive vacuoles… read more here.
Keywords: gas; nox2 ros; membrane; endothelial cells ... See more keywords