High nuclear NADPH oxidase 4 expression levels are correlated with cancer development and poor prognosis in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Pathology"
DOI: 10.1016/j.pathol.2019.05.004
Abstract: NADPH oxidase (NOX) is a key source of reactive oxygen species (ROS). This study aimed to verify NOX2 and NOX4 expression levels in hepatocellular carcinoma (HCC). A total of 134 matched pairs of HCC cells… read more here.
Keywords: hcc; nox2 nox4; expression; expression levels ... See more keywords
NOX4 as an emerging prognostic and immunological biomarker across pan-cancer analyses
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DOI: 10.1038/s41598-025-03499-2
Abstract: Despite extensive research highlighting the pivotal role of NOX4 in the development of various malignancies, no systematic pan-cancer analysis has been conducted to evaluate its comprehensive prognostic value and potential immunological functions. In this study,… read more here.
Keywords: cancer; nox4 emerging; nox4 expression; pan cancer ... See more keywords
Sequential Changes in NOX4 Expression, Oxidative Stress Indices, PIIINP, and Liver Histopathology During Hepatocellular Carcinogenesis Induced in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16914
Abstract: Hepatocellular carcinoma (HCC) is a chronic disease caused by complex histological and biochemical changes related to oxidative stress leading to fibrosis, cirrhosis, and malignancy. Knowing the sequential changes in different stages of HCC development is… read more here.
Keywords: changes nox4; oxidative stress; sequential changes; nox4 expression ... See more keywords
Prognostic Value of NOX4 Expression in Cancer Patients: A Systematic Review and Meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/8567642
Abstract: Background Recent studies have shown that nicotinamide adenosine dinucleotide phosphate oxidase 4 (NOX4) is related to cancer development, proliferation, invasion, epithelial-to-mesenchymal transition, and metastasis. The prognostic value of NOX4 expression although has been reported in… read more here.
Keywords: cancer; prognostic value; expression; value nox4 ... See more keywords
NOX4 expression and distal arteriolar remodeling correlate with pulmonary hypertension in COPD
Sign Up to like & getrecommendations! Published in 2018 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-018-0680-y
Abstract: BackgroundPulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is suggested as the consequence of emphysematous destruction of vascular bed and hypoxia of pulmonary microenvironment, mechanisms underpinning its pathogenesis however remain elusive. The dysregulated expression… read more here.
Keywords: arteriolar remodeling; pulmonary vascular; copd; expression ... See more keywords
High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
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DOI: 10.1242/bio.055012
Abstract: ABSTRACT Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear. This study investigated the regulatory role… read more here.
Keywords: apoptosis; phospho; smad3; pka ... See more keywords
Morroniside Inhibits H2O2-Induced Podocyte Apoptosis by Down-Regulating NOX4 Expression Controlled by Autophagy In Vitro
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.533809
Abstract: Podocyte apoptosis is the common pathological basis for the progression of various kidney diseases. The overexpression of NOX4, a key enzyme involved in oxidative stress, has been proved to participate in the occurrence of podocyte… read more here.
Keywords: podocyte apoptosis; apoptosis; morroniside; nox4 expression ... See more keywords