Resiniferatoxin Hampers the Nocifensive Response of Caenorhabditis elegans to Noxious Heat, and Pathway Analysis Revealed that the Wnt Signaling Pathway is Involved.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03471-2
Abstract: Resiniferatoxin (RTX) is a metabolite extracted from Euphorbia resinifera. RTX is a potent capsaicin analog with specific biological activities resulting from its agonist activity with the transient receptor potential channel vanilloid subfamily member 1 (TRPV1).… read more here.
Keywords: wnt signaling; elegans noxious; noxious heat; nocifensive response ... See more keywords
Bursty spike trains of antennal thermo- and bimodal hygro-thermoreceptor neurons encode noxious heat in elaterid beetles.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thermal biology"
DOI: 10.1016/j.jtherbio.2018.01.008
Abstract: The main purpose of this study was to explain the internal fine structure of potential antennal thermo- and hygroreceptive sensilla, their innervation specifics, and responses of the sensory neurons to thermal and humidity stimuli in… read more here.
Keywords: bimodal hygro; antennal thermo; noxious heat; spike ... See more keywords
Heat sensing involves a TRiPlet of ion channels
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DOI: 10.1111/bph.14812
Abstract: Detecting and avoiding noxious heat is crucial to prevent burn injury. While the nociceptor neurons involved in conveying heat‐induced pain were identified more than a century ago, the molecular sensors responsible for detecting noxious heat… read more here.
Keywords: heat sensing; ion channels; noxious heat; heat ... See more keywords
Stress-induced antinociception to noxious heat requires α1A-adrenaline receptors of spinal inhibitory neurons in mice
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Brain"
DOI: 10.1186/s13041-021-00895-3
Abstract: It is well known that acute exposure to physical stress produces a transient antinociceptive effect (called stress-induced analgesia [SIA]). One proposed mechanism for SIA involves noradrenaline (NA) in the central nervous system. NA has been… read more here.
Keywords: noxious heat; adrenaline receptors; inhibitory neurons; stress induced ... See more keywords