Nucleophosmin 1: from its pathogenic role to a tantalizing therapeutic target in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2067939
Abstract: ABSTRACT Nucleophosmin 1 (NPM1, also known as B23) is a multifunctional protein involved in a variety of cellular processes, including ribosomal maturation, centrosome replication, maintenance of genomic stability, cell cycle control, and apoptosis. NPM1 is… read more here.
Keywords: therapeutic target; role; leukemia; acute myeloid ... See more keywords
Mutant NPM1 maintains RASGRP3 protein stability via interaction with MID1 to promote acute myeloid leukemia cell proliferation and autophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad023
Abstract: BACKGROUND/OBJECTIVE Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with high mortality in the world. NPM1 gene mutations are a frequent occurrence in AML leading to abnormal autophagy. While the mechanism of NPM1 mutation-driven… read more here.
Keywords: myeloid leukemia; cell proliferation; rasgrp3; acute myeloid ... See more keywords
Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia
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DOI: 10.1158/2159-8290.cd-22-0424
Abstract: Mutant NPM1 in leukemia obtains neomorphic activity to hijack active HOXA/B and MEIS1 transcription on chromatin via the association of XPO1 and blocks the histone deacetylase activity associated with myeloid differentiation. read more here.
Keywords: transcriptional hubs; mutant npm1; leukemia; hijacks transcriptional ... See more keywords