The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AML
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25517
Abstract: Acute myeloid leukemia (AML) is a genetically heterogeneous disease with a clinical course predicted by recurrent cytogenetic abnormalities and/or gene mutations. The NPM1 insertion mutations define the largest distinct genetic subset, ∼30% of AML, and… read more here.
Keywords: dnmt3a; overall survival; npm1 dnmt3a; inferior overall ... See more keywords
NPM1 and DNMT3A mutations are associated with distinct blast immunophenotype in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2073050
Abstract: ABSTRACT The immune system is important for elimination of residual leukemic cells during acute myeloid leukemia (AML) therapy. Anti-leukemia immune response can be inhibited by various mechanisms leading to immune evasion and disease relapse. Selected… read more here.
Keywords: myeloid leukemia; leukemia; npm1 dnmt3a; acute myeloid ... See more keywords
Acute Myeloid Leukemia with Eosinophilia (FAB AML-M4Eo) having NPM1/DNMT3A/IDH2 Gene Mutations and t(5;12)(q31;p13).
Sign Up to like & getrecommendations! Published in 2025 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2024.240802
Abstract: BACKGROUND AML-M4Eo is a type of AML characterized by malignant proliferation of granulocyte and monocyte precursor cells accompanied by eosinophilia. Patients present as anemia, infection, bleeding, and tissue and organ infiltration. MICM classification makes the… read more here.
Keywords: gene mutations; dnmt3a idh2; aml m4eo; npm1 dnmt3a ... See more keywords