The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AML
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25517
Abstract: Acute myeloid leukemia (AML) is a genetically heterogeneous disease with a clinical course predicted by recurrent cytogenetic abnormalities and/or gene mutations. The NPM1 insertion mutations define the largest distinct genetic subset, ∼30% of AML, and… read more here.
Keywords: dnmt3a; overall survival; npm1 dnmt3a; inferior overall ... See more keywords
NPM1 and DNMT3A mutations are associated with distinct blast immunophenotype in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2073050
Abstract: ABSTRACT The immune system is important for elimination of residual leukemic cells during acute myeloid leukemia (AML) therapy. Anti-leukemia immune response can be inhibited by various mechanisms leading to immune evasion and disease relapse. Selected… read more here.
Keywords: myeloid leukemia; leukemia; npm1 dnmt3a; acute myeloid ... See more keywords