LAUSR

Dynamics of molecular response in AML patients with NPM1 and FLT3 mutations undergoing allogeneic stem cell transplant

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1 Published in 2017 at "Bone Marrow Transplantation"

DOI: 10.1038/bmt.2017.82

Abstract: Dynamics of molecular response in AML patients with NPM1 and FLT3 mutations undergoing allogeneic stem cell transplant read more here.

Keywords: aml patients; dynamics molecular; molecular response; response aml ... See more keywords

Impact of NPM1/FLT3-ITD genotypes defined by the2017 European LeukemiaNet in patients with acute myeloid leukemia.

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1 Published in 2019 at "Blood"

DOI: 10.1182/blood.2019002697

Abstract: Patients with AML harboring FLT3 internal tandem duplications (ITD) have poor outcomes, in particular AML with a high ({greater than or equal to}0.5) mutant-to-wildtype allelic ratio (AR). The 2017 European LeukemiaNet (ELN) recommendations defined four… read more here.

Keywords: itd genotypes; risk; flt3; flt3 itd ... See more keywords

Prognostic impact of NPM1 and FLT3 mutations in patients with AML in first remission treated with oral azacitidine.

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2 Published in 2022 at "Blood"

DOI: 10.1182/blood.2022016293

Abstract: The randomized, placebo-controlled, phase 3 QUAZAR AML-001 trial (NCT01757535) evaluated oral azacitidine (Oral-AZA) in patients with AML in first remission after intensive chemotherapy (IC) who were not candidates for hematopoietic stem cell transplant. Eligible patients… read more here.

Keywords: aza; oral azacitidine; npm1 flt3; aml first ... See more keywords

Prognostic Relevance of NPM1 and FLT3 Mutations in Acute Myeloid Leukaemia, Longterm Follow-Up—A Single Center Experience

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2 Published in 2022 at "Cancers"

DOI: 10.3390/cancers14194716

Abstract: Simple Summary In acute myeloid leukemia, molecular genetics abnormalities, particularly NPM1 and FLT3 mutations, have a recognized prognostic role in the ELN risk classification and guide treatment decisions, especially since the availability of FLT3-targeted drugs.… read more here.

Keywords: flt3; itd; npm1 flt3; survival ... See more keywords

NPM1 and FLT3-TKD mutations are enriched in patients with leukemia cutis.

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1 Published in 2020 at "Dermatology online journal"

DOI: 10.5070/d3267049552

Abstract: Leukemia cutis (LC) is a dermatologic manifestation of leukemia. Its clinical implications for the patient and the biological mechanism behind the manifestation of LC are unknown. The oncology community is increasingly utilizing mutations to classify… read more here.

Keywords: leukemia cutis; flt3 tkd; cutis; npm1 flt3 ... See more keywords