Clinical significance of prothrombin G20210A mutation in homozygous patients
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DOI: 10.1002/ajh.24859
Abstract: (P< .0001), low hemoglobin (P5 .0009), high absolute lymphocyte count (P5 .02), higher serum lactate dehydrogenase levels (P5 .023), PB blast % (P< .0001), BM blast % (P< .0001), 2016WHO morphological subtype CMML-2 (P< .0001),… read more here.
Keywords: g20210a mutation; significance prothrombin; prothrombin g20210a; mutation homozygous ... See more keywords
Molecular heterogeneity and measurable residual disease of rare NPM1 mutations in acute myeloid leukemia: a nationwide experience from the GBMHM study group
Sign Up to like & getrecommendations! Published in 2022 at "Leukemia"
DOI: 10.1038/s41375-022-01534-z
Abstract: TO THE EDITOR Nucleophosmin (NPM1)-mutated acute myeloid leukemia (AML) is a recognized entity related to distinctive biological, clinical, and prognostic features. Nearly all NPM1 variants are frame-shift mutations located in exon 11, inducing the insertion… read more here.
Keywords: study; acute myeloid; npm1 mutations; myeloid leukemia ... See more keywords
NPM1 mutation with DNMT3A wild type defines a subgroup of MDS with particularly favourable outcomes after decitabine therapy
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16628
Abstract: Myelodysplastic syndrome (MDS) consists of a heterogeneous group of clonal haematopoietic stem cell disorders that are characterized by peripheral cytopenia, hypercellular bone marrow (BM), and increased mortality due to the progression to acute myeloid leukaemia… read more here.
Keywords: dnmt3a; response; decitabine therapy; npm1 mutations ... See more keywords
Comprehensive Single-Cell RNA-Sequencing Mapping of Primary Acute Myeloid Leukemias and Profiling of NPM1-Mutated Cells
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DOI: 10.1182/blood-2018-99-111390
Abstract: Introduction: Acute myeloid leukemia (AML) evolution is a multistep process in which cells evolve from hematopoietic stem and progenitor cells (HSPCs) that acquire genetic anomalies, such as chromosomal rearrangements and mutations, which define distinct subgroups.… read more here.
Keywords: single cell; equity ownership; rna sequencing; npm1 mutations ... See more keywords
Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML
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DOI: 10.1182/bloodadvances.2022008316
Abstract: Key Points • In relapsed or refractory AML, mutated NPM1 has no impact on the risk of relapse or death.• The addition of venetoclax to salvage treatment for NPM1-mutated AML is associated with improved outcomes. read more here.
Keywords: refractory aml; clinical outcomes; associated npm1; npm1 mutations ... See more keywords
Prognostic relevance of combined IDH1 and NPM1 mutations in the intermediate cytogenetic de novo acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2021.67.3.12
Abstract: Despite the great advance in treatment, cytogenetically normal Acute myeloid leukemia (CN-AML) is still a challenging entity. The discovery of IDH1 mutation in AML together with the frequent co-mutations; NPM1 and FLT3-ITD throughs a new… read more here.
Keywords: aml; npm1 mutations; acute myeloid; idh1 npm1 ... See more keywords