Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart.
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/circresaha.120.317045
Abstract: Rationale: Atrial and B-type natriuretic peptide, encoded by the clustered genes Nppa and Nppb, are important prognostic, diagnostic and therapeutic proteins in cardiac disease. The spatio-temporal expression pattern and stress-induction of the Nppa and Nppb… read more here.
Keywords: nppa nppb; expression; cluster; super enhancer ... See more keywords
Regulatory Landscapes of Nppa and Nppb.
Sign Up to like & getrecommendations! Published in 2021 at "Circulation Research"
DOI: 10.1161/circresaha.120.318495
Abstract: The coordinated expression of the ≈20 000 genes in the human genome is achieved by the concerted action of almost 1 million cis-regulatory regions.1 Many of these regions correspond to enhancers, controlling gene expression through… read more here.
Keywords: nppa nppb; expression; regulatory elements; landscapes nppa ... See more keywords