Design of PEG-grafted-PLA nanoparticles as oral permeability enhancer for P-gp substrate drug model Famotidine
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2017.1290155
Abstract: Abstract Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylene glycol (PEG) is a known P-gp inhibitor. Dispersion of Famotidine (a P-gp substrate) within PEGylated nanoparticles (NPs)… read more here.
Keywords: design peg; nps prepared; famotidine; permeability ... See more keywords
Hepatotropic Peptides Grafted onto Maleimide-Decorated Nanoparticles: Preparation, Characterization and In Vitro Uptake by Human HepaRG Hepatoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14122447
Abstract: We recently demonstrated the strong tropism of George Baker (GB) Virus A (GBVA10-9) and Plasmodium circumsporozoite protein (CPB) derived synthetic peptides towards hepatoma cells. In a first approach, these peptides were covalently bound to poly(benzyl… read more here.
Keywords: maleimide; pmlabe73; nps prepared; decorated nanoparticles ... See more keywords