Expression of the NRF2 Target Gene NQO1 Is Enhanced in Mononuclear Cells in Human Chronic Kidney Disease
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DOI: 10.1155/2017/9091879
Abstract: Reduced nuclear factor erythroid 2-related factor 2 (NRF2) pathway activity was reported in models of chronic kidney disease (CKD). Pharmacological activation of NRF2 is supposed to improve renal function, but data concerning the NRF2 activity… read more here.
Keywords: chronic kidney; expression; nqo1; gene ... See more keywords
Osthole Induces Apoptosis and Caspase-3/GSDME-Dependent Pyroptosis via NQO1-Mediated ROS Generation in HeLa Cells
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DOI: 10.1155/2022/8585598
Abstract: Osthole is a natural coumarin which has been proved to inhibit growth of cancer cells by inducing cell death, while its mechanism was considered to be just caused by apoptosis. In our study, we found… read more here.
Keywords: apoptosis; pyroptosis; gsdme; caspase ... See more keywords
Abstract 2169: NAD(P)H: quinone oxidoreductase 1 (NQO1)- A viable biomarker in colorectal cancer
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DOI: 10.1158/1538-7445.am2023-2169
Abstract: Background/Objective: Colorectal cancer (CRC) is aggressive and widespread (3rd among malignancies) in the United States. NAD(P)H: Quinone Oxidoreductase 1 (NQO1) is an enzyme that contributes to chemoprotection for CRC. The aim of this meta-analysis is… read more here.
Keywords: bbi 608; nad quinone; crc; colorectal cancer ... See more keywords
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis
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DOI: 10.26508/lsa.202201667
Abstract: NQO1 catalyzes the reduction of tanshinones to detoxify lipid peroxyl radicals and inhibit ferroptosis both in vitro and in vivo, providing a molecular mechanism for the therapeutic effects of tanshinones, such as cardiac protection. Ferroptosis… read more here.
Keywords: functions coenzyme; tanshinone; gain function; tanshinone functions ... See more keywords
Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
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DOI: 10.3390/jpm12050747
Abstract: HIF-1α is a master regulator of oxygen homeostasis involved in different stages of cancer development. Thus, HIF-1α inhibition represents an interesting target for anti-cancer therapy. It was recently shown that the HIF-1α interaction with NQO1… read more here.
Keywords: function; chaperone; targeting hif; stability ... See more keywords