SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.29
Abstract: Nuclear receptor NR4A1 has been implicated as a key regulator in a wide range of pathophysiological responses. As an immediate early response gene, NR4A1 can be rapidly and potently induced by a variety of stimuli.… read more here.
Keywords: macrophage cell; ubiquitination nr4a1; nr4a1; cell death ... See more keywords
Abstract 2326: Proteolysis-targeting chimera against NR4A1 for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2326
Abstract: Introduction: Modulating tumor-infiltrating immune cells is the key mission for the development of cancer immunotherapy. However, current immunotherapies including immune-checkpoint inhibitors (ICI) have limited patient response rates and some with adverse effects, which drives us… read more here.
Keywords: nr4a1; v04; tumor; cancer ... See more keywords
Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and Biophysical Research Communications"
DOI: 10.2210/pdb6lc1/pdb
Abstract: Abstract The nuclear receptor NR4A subfamily (NR4A1/NGFI-B, NR4A2/Nurr1 and NR4A3/NOR-1) can recognize different classes of DNA response elements either as a monomer, homodimer, or heterodimer. In this study, we determined the structure of the NR4A1… read more here.
Keywords: structural basis; gene; pituitary proopiomelanocortin; nr4a1 ... See more keywords