Abstract B019: ASO-mediated NRAS knockdown overcomes gilteritinib late resistance in FLT3-AML
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DOI: 10.1158/1557-3125.ras23-b019
Abstract: The internal tandem duplication of the FLT3 receptor (FLT3-ITD) leads to constitutive receptor activation and is one of the most common mutations (~30%) in acute myeloid leukemia (AML), resulting in poor prognosis. Multiple FLT3 inhibitors… read more here.
Keywords: flt3; nras mrna; aso; resistance ... See more keywords