MEK inhibition may increase survival of NRAS-mutated melanoma patients treated with checkpoint blockade: Results of a retrospective multicentre analysis of 364 patients.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.04.010
Abstract: BACKGROUND Melanoma harbours genetic alterations in genes such as BRAF, NRAS and KIT. Activating NRAS mutations are present in about 20% of melanomas. Even though BRAF mutations can be effectively targeted with specific inhibitors, this approach… read more here.
Keywords: melanoma; nras mutated; inhibition; nras wildtype ... See more keywords
MUG-Mel2, a novel highly pigmented and well characterized NRAS mutated human melanoma cell line
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02197-y
Abstract: NRAS mutation in melanoma has been associated with aggressive tumor biology and poor prognosis. Although targeted therapy has been tested for NRAS mutated melanoma, response rates still appear much weaker, than in BRAF mutated melanoma.… read more here.
Keywords: melanoma; cell line; nras mutated; mug mel2 ... See more keywords
Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia
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DOI: 10.1038/s41598-020-69194-6
Abstract: The mutational spectrum and prognostic factors of NRAS-mutated (NRASmut) acute myeloid leukemia (AML) are largely unknown. We performed next-generation sequencing (NGS) in 1,149 cases of de novo AML and discovered 152 NRASmut AML (13%). Of… read more here.
Keywords: nras mutated; prognostic factors; mutational spectrum; myeloid leukemia ... See more keywords
Targeted treatment of advanced NRAS-mutated melanoma
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DOI: 10.18632/oncotarget.21388
Abstract: NRAS-mutations most commonly in codon 61 (Q61R or Q61K) can be detected in around 20% of cutaneous melanomas and have been found more frequently in nodular primary melanomas and primary tumors from skin sites with… read more here.
Keywords: melanoma; inhibitor; nras mutated; trial ... See more keywords