Effects of NRAS Mutations on Leukemogenesis and Targeting of Children With Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.712484
Abstract: Through the advancements in recent decades, childhood acute lymphoblastic leukemia (ALL) is gradually becoming a highly curable disease. However, the truth is there remaining relapse in ∼15% of ALL cases with dismal outcomes. RAS mutations,… read more here.
Keywords: acute lymphoblastic; ras mutations; leukemogenesis; nras mutations ... See more keywords
Association of NRAS Mutation With Clinical Outcomes of Anti-PD-1 Monotherapy in Advanced Melanoma: A Pooled Analysis of Four Asian Clinical Trials
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.691032
Abstract: Background Anti-PD-1 monotherapy is the standard therapy for advanced melanoma patients, including those with NRAS mutations. The influence of NRAS mutation on immunotherapy, especially in noncutaneous melanoma, is largely uncharacterized. Materials and Methods We analyzed… read more here.
Keywords: melanoma; advanced melanoma; nras mutation; nras mutations ... See more keywords
Clinical profile in KMT2A-SEPT6-positive acute myeloid leukemia: Does it often co-occur with NRAS mutations?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.890959
Abstract: Background The KMT2A-SEPT6 fusion gene is a relatively rare genetic event in leukemia. Its clinical characteristics and prognosis, especially the profile of co-occurring gene mutations remain unclear. Methods We retrospectively analyzed the characteristics of four… read more here.
Keywords: kmt2a sept6; myeloid leukemia; acute myeloid; nras mutations ... See more keywords
The predictive value of KRAS and NRAS mutations in metastatic colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Medical Journal of the Islamic Republic of Iran"
DOI: 10.34171/mjiri.34.39
Abstract: 1. Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran 2. Qom Islamic Azad University, Qom, Iran ↑What is “already known” in this topic: The RAS oncogene family is widely accepted and is the… read more here.
Keywords: mutations metastatic; kras nras; value kras; nras mutations ... See more keywords