MEK inhibition may increase survival of NRAS-mutated melanoma patients treated with checkpoint blockade: Results of a retrospective multicentre analysis of 364 patients.
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DOI: 10.1016/j.ejca.2018.04.010
Abstract: BACKGROUND Melanoma harbours genetic alterations in genes such as BRAF, NRAS and KIT. Activating NRAS mutations are present in about 20% of melanomas. Even though BRAF mutations can be effectively targeted with specific inhibitors, this approach… read more here.
Keywords: melanoma; nras mutated; inhibition; nras wildtype ... See more keywords