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1
Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2076
Abstract: Mitochondrial dysfunction has been associated with the pathogenesis of a variety of neurodegenerative diseases. Sitagliptin is a dipeptidyl‐peptidase‐4 (DPP‐4) inhibitor that has been approved for the treatment of type 2 diabetes (T2DM). In the current…
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Keywords:
nrf1 tfam;
sitagliptin;
pgc nrf1;
expression ... See more keywords
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2
Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1055126
Abstract: Background The activation of peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) stimulates the transcription of the downstream target proteins, mitochondrial transcription factor A (TFAM) and nuclear respiratory factor 1 (NRF1), which induces mitochondrial biogenesis and promotes…
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Keywords:
nrf1 tfam;
pgc nrf1;
mitochondrial function;
agr ... See more keywords