Nrf2 mediates the antinociceptive activity of dexmedetomidine in an acute inflammatory visceral pain rat model by activating the NF‐κB sensor
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3456
Abstract: Dexmedetomidine (DEX) is a highly selective α2 adrenoceptor agonist. In this study, we evaluated the antalgic effect of DEX on acetic acid–induced acute inflammatory visceral pain (AIVP) in rats. Additionally, we evaluated the role of… read more here.
Keywords: acute inflammatory; dex; nrf2; model ... See more keywords
Swimming training mitigates the sex-specific hepatic disruption caused by a high-calorie diet: The putative modulation of Nrf2/Keap-1 pathway in male mice.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3631
Abstract: This study investigated whether swimming protocol induces adaptations to sex-specific oxidative stress and Nrf2/Keap-1 pathway in the liver of mice fed a high-calorie diet (HCD) during the early life period. Male and female Swiss mice… read more here.
Keywords: sex specific; nrf2; male mice; high calorie ... See more keywords
In vitro exosomal transfer of Nrf2 led to the oxaliplatin resistance in human colorectal cancer LS174T cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3703
Abstract: Chemotherapy resistance is a serious pitfall in the treatment of colon cancers (CCs). Previous studies have found that exosomes (Exo) play a pivotal role in tumor drug resistance via the transfer of proteins and genetic… read more here.
Keywords: transfer; nrf2; ls174t cells; resistance ... See more keywords
Effect of di(2-ethylhexyl) phthalate on Nrf2-regulated glutathione homeostasis in mouse kidney
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01127-8
Abstract: Environmental toxicants such as phthalate have been involved in multiple health disorders including renal diseases. Oxidative damage is implicated in many alterations caused by phthalate especially the di(2-ethylhexyl) phthalate (DEHP), which is the most useful… read more here.
Keywords: protein; phthalate; nrf2; ethylhexyl phthalate ... See more keywords
Cloning, functional characterization and expression analysis of nuclear factor erythroid-2-related factor-2 of golden pompano (Trachinotus ovatus) and its response to air-exposure
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture Reports"
DOI: 10.1016/j.aqrep.2020.100580
Abstract: Abstract Nrf2 is an important component of Nrf2-ARE signaling pathway. However, information about Nrf2 in golden pompano (Trachinotus ovatus) is quiet limited. Thus, the full length of Nrf2 was cloned from T. ovatus in this… read more here.
Keywords: expression; ovatus; factor; nrf2 ... See more keywords
Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl4.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174628
Abstract: Combination of monoammonium glycyrrhizinate and cysteine hydrochloride (MG-CH) has been used in the treatment of chronic liver disease for decades, however, its mechanism is still unclear. Our previous studies showed that MG-CH confers the optimal… read more here.
Keywords: anti fibrotic; p62; nrf2; effect ... See more keywords
Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium
Sign Up to like & getrecommendations! Published in 2017 at "Redox Biology"
DOI: 10.1016/j.redox.2017.04.038
Abstract: Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against oxidative stress and establishes a redox tone permissive for cell signaling. The molecular regulation of… read more here.
Keywords: state; redox homeostasis; antioxidant response; nrf2 ... See more keywords
Nrf2 exerts cell‐autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative
Sign Up to like & getrecommendations! Published in 2017 at "Translational Research"
DOI: 10.1016/j.trsl.2016.12.002
Abstract: &NA; The transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) governs antioxidant, innate immune and cytoprotective responses and its deregulation is prominent in chronic inflammatory conditions. To examine the hypothesis that Nrf2 might be… read more here.
Keywords: nrf2; nrf2 exerts; systemic sclerosis; exerts cell ... See more keywords
ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01909
Abstract: Proteolysis-targeting chimera (PROTAC) technology has emerged as a potential strategy to degrade "undruggable" proteins in recent years. Nrf2, an aberrantly activated transcription factor in cancer, is generally considered undruggable as lacking active sites or allosteric… read more here.
Keywords: nrf2 mafg; degradation; mafg heterodimer; nrf2 ... See more keywords
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1800431115
Abstract: Significance The molecular clock provides an anticipatory mechanism, allowing organisms to prepare and respond to daily changes in the external environment. The response of the innate immune system to pathogenic threats is dependent on time… read more here.
Keywords: bmal1; response; nrf2; molecular clock ... See more keywords
Dynamic cell type‐specific expression of Nrf2 after traumatic brain injury in mice
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14399
Abstract: Nrf2 plays a pivotal role in antioxidant response and anti‐inflammation after traumatic brain injury (TBI), and its deletion aggravates TBI‐induced brain damage. Previous studies have demonstrated that Nrf2 is activated post TBI, but dynamic changes… read more here.
Keywords: expression; type specific; cell type; nrf2 ... See more keywords