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   Articles with "nrf2" as a keyword



Nrf2 mediates the antinociceptive activity of dexmedetomidine in an acute inflammatory visceral pain rat model by activating the NF‐κB sensor

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recommendations! Published in 2019 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.3456

Abstract: Dexmedetomidine (DEX) is a highly selective α2 adrenoceptor agonist. In this study, we evaluated the antalgic effect of DEX on acetic acid–induced acute inflammatory visceral pain (AIVP) in rats. Additionally, we evaluated the role of… read more here.

Keywords: acute inflammatory; dex; nrf2; model ... See more keywords

Swimming training mitigates the sex-specific hepatic disruption caused by a high-calorie diet: The putative modulation of Nrf2/Keap-1 pathway in male mice.

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recommendations! Published in 2021 at "Cell biochemistry and function"

DOI: 10.1002/cbf.3631

Abstract: This study investigated whether swimming protocol induces adaptations to sex-specific oxidative stress and Nrf2/Keap-1 pathway in the liver of mice fed a high-calorie diet (HCD) during the early life period. Male and female Swiss mice… read more here.

Keywords: sex specific; nrf2; male mice; high calorie ... See more keywords

In vitro exosomal transfer of Nrf2 led to the oxaliplatin resistance in human colorectal cancer LS174T cells

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recommendations! Published in 2022 at "Cell Biochemistry and Function"

DOI: 10.1002/cbf.3703

Abstract: Chemotherapy resistance is a serious pitfall in the treatment of colon cancers (CCs). Previous studies have found that exosomes (Exo) play a pivotal role in tumor drug resistance via the transfer of proteins and genetic… read more here.

Keywords: transfer; nrf2; ls174t cells; resistance ... See more keywords
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Effect of di(2-ethylhexyl) phthalate on Nrf2-regulated glutathione homeostasis in mouse kidney

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recommendations! Published in 2020 at "Cell Stress and Chaperones"

DOI: 10.1007/s12192-020-01127-8

Abstract: Environmental toxicants such as phthalate have been involved in multiple health disorders including renal diseases. Oxidative damage is implicated in many alterations caused by phthalate especially the di(2-ethylhexyl) phthalate (DEHP), which is the most useful… read more here.

Keywords: protein; phthalate; nrf2; ethylhexyl phthalate ... See more keywords

Cloning, functional characterization and expression analysis of nuclear factor erythroid-2-related factor-2 of golden pompano (Trachinotus ovatus) and its response to air-exposure

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recommendations! Published in 2021 at "Aquaculture Reports"

DOI: 10.1016/j.aqrep.2020.100580

Abstract: Abstract Nrf2 is an important component of Nrf2-ARE signaling pathway. However, information about Nrf2 in golden pompano (Trachinotus ovatus) is quiet limited. Thus, the full length of Nrf2 was cloned from T. ovatus in this… read more here.

Keywords: expression; ovatus; factor; nrf2 ... See more keywords

Up-regulation of Nrf2/P62/Keap1 involves in the anti-fibrotic effect of combination of monoammonium glycyrrhizinate and cysteine hydrochloride induced by CCl4.

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recommendations! Published in 2021 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2021.174628

Abstract: Combination of monoammonium glycyrrhizinate and cysteine hydrochloride (MG-CH) has been used in the treatment of chronic liver disease for decades, however, its mechanism is still unclear. Our previous studies showed that MG-CH confers the optimal… read more here.

Keywords: anti fibrotic; p62; nrf2; effect ... See more keywords

Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium

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recommendations! Published in 2017 at "Redox Biology"

DOI: 10.1016/j.redox.2017.04.038

Abstract: Redox homeostasis regulates key cellular signaling pathways in both physiology and pathology. The cell's antioxidant response provides a defense against oxidative stress and establishes a redox tone permissive for cell signaling. The molecular regulation of… read more here.

Keywords: state; redox homeostasis; antioxidant response; nrf2 ... See more keywords

Nrf2 exerts cell‐autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

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recommendations! Published in 2017 at "Translational Research"

DOI: 10.1016/j.trsl.2016.12.002

Abstract: &NA; The transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) governs antioxidant, innate immune and cytoprotective responses and its deregulation is prominent in chronic inflammatory conditions. To examine the hypothesis that Nrf2 might be… read more here.

Keywords: nrf2; nrf2 exerts; systemic sclerosis; exerts cell ... See more keywords

The Ameliorative Role of Lico A on Aflatoxin B1-Triggered Hepatotoxicity Partially by Activating Nrf2 Signal Pathway.

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recommendations! Published in 2024 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.3c05776

Abstract: Aflatoxin B1 (AFB1) is one of the most harmful and toxic mycotoxins in foods and feeds, posing a serious health risk to both humans and animals, especially its hepatotoxicity. Nuclear factor-erythroid 2-related factor 2 (Nrf2),… read more here.

Keywords: hepatotoxicity; lico; liver injury; nrf2 ... See more keywords

Nrf2 Alleviates Colistin-Induced Nephrotoxicity by Suppressing Ferroptosis via GPX4-Mediated Lipid Peroxidation and Mitochondrial Protection.

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.4c13030

Abstract: Colistin (CS)-induced nephrotoxicity remains a major clinical challenge, with its mechanisms not fully understood. This study aimed to investigate the involvement of ferroptosis and the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway in… read more here.

Keywords: colistin induced; induced nephrotoxicity; ferroptosis; nrf2 ... See more keywords

ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer.

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recommendations! Published in 2023 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c01909

Abstract: Proteolysis-targeting chimera (PROTAC) technology has emerged as a potential strategy to degrade "undruggable" proteins in recent years. Nrf2, an aberrantly activated transcription factor in cancer, is generally considered undruggable as lacking active sites or allosteric… read more here.

Keywords: nrf2 mafg; degradation; mafg heterodimer; nrf2 ... See more keywords