Novel NRF2‐activated cancer treatments utilizing synthetic lethality
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DOI: 10.1002/iub.2680
Abstract: The KEAP1‐NRF2 pathway regulates the main inducible cellular response to oxidative and electrophilic stresses. Activating mutations in the KEAP1‐NRF2 pathway occur commonly in human cancer, where they contribute to the formation of aggressive tumours that… read more here.
Keywords: activated cancer; treatments utilizing; nrf2 activated; cancer treatments ... See more keywords
Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
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DOI: 10.1038/s41467-020-19593-0
Abstract: Transcriptional dysregulation, which can be caused by genetic and epigenetic alterations, is a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2, is often aberrantly activated in non-small cell lung cancers (NSCLCs) and… read more here.
Keywords: activated non; tumor initiating; non small; nrf2 activated ... See more keywords