Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose‐Exposed Cardiomyocytes
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DOI: 10.1002/jcb.25785
Abstract: Hyperglycemia leads to excess reactive oxygen species (ROS) generation, which causes many diabetic complications, such as cardiomyopathy. Nuclear factor erythroid 2‐related factor 2 (Nrf2), a redox‐sensing transcription factor, can up‐regulate its downstream antioxidant gene expressions… read more here.
Keywords: high glucose; activation; pkc; cell ... See more keywords
Chlorogenic acid improves diabetic retinopathy by alleviating blood‐retinal‐barrier dysfunction via inducing Nrf2 activation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7401
Abstract: As one of the major diabetic microvascular complications, diabetic retinopathy (DR) is mainly initiated by the blood‐retinal barrier (BRB) dysfunction. Chlorogenic acid (CGA) is a natural polyphenolic compound in Lonicerae Japonicae Flos, which traditionally has… read more here.
Keywords: blood retinal; nrf2 activation; barrier; dysfunction ... See more keywords
Activation of the Nrf2 response by oleanolic acid oxime morpholide (3-hydroxyiminoolean-12-en-28-oic acid morpholide) is associated with its ability to induce apoptosis and inhibit proliferation in HepG2 hepatoma cells.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173307
Abstract: Our previous study demonstrated that new oleanolic acid oxime (OAO) derivatives and their conjugates with aspirin (ASP) inhibit NF-κB activation. Evidence exists that the downregulation of NF-κB negatively interferes with the Nrf2 signaling pathway. This… read more here.
Keywords: activation; acid; oleanolic acid; nrf2 activation ... See more keywords
Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2018.07.020
Abstract: The trace element selenium (Se) contributes to redox signaling, antioxidant defense, and immune responses in critically ill neonatal and adult patients. Se is required for the synthesis and function of selenoenzymes including thioredoxin (Trx) reductase-1… read more here.
Keywords: supplementation; activation; factor; nuclear factor ... See more keywords
Protection from Cr(VI)‐induced malignant cell transformation and tumorigenesis of Cr(VI)‐transformed cells by luteolin through Nrf2 signaling
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.04.016
Abstract: &NA; Cr(VI) is a well known environmental carcinogen, but its mechanism of action and the measures required to mitigate its effects remain to be investigated. Our previous studies showed that exposure of human bronchial epithelial… read more here.
Keywords: transformed cells; tumorigenesis; cell; transformation ... See more keywords
Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02552-w
Abstract: Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator, Kelch-like ECH associated protein 1 (Keap1), are at the interface between redox and intermediary metabolism. Nrf2 activation is protective in… read more here.
Keywords: development; colorectal cancer; nrf2 activation; activation ... See more keywords
TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid-β Neuropathology via Akt/Gsk3β-Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/1544244
Abstract: Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder for which there is no effective therapeutic strategy. PcActx peptide from the transcriptome of zoantharian Palythoa caribaeorum has recently been identified and verified as a… read more here.
Keywords: nrf2 activation; pcactx peptide; akt gsk3;
NRF2 Activation in Cancer: From DNA to Protein.
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DOI: 10.1158/0008-5472.can-18-2723
Abstract: The Cancer Genome Atlas catalogued alterations in the Kelch-like ECH-associated protein 1 and nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway in 6.3% of patient samples across 226 studies, with significant enrichment in lung… read more here.
Keywords: activation cancer; nrf2 activation; cancer dna; cancer ... See more keywords
Low-Dose Dose–Response for In Vitro Nrf2-ARE Activation in Human HepG2 Cells
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DOI: 10.1177/1559325817699696
Abstract: Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-like factor 2-related factor 2 (Nrf2), and the antioxidant response element (ARE) are interacting components of a master regulatory signaling pathway that coordinates redox homeostasis, cytoprotective responses,… read more here.
Keywords: dose response; response; vitro nrf2; activation human ... See more keywords
The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Molecules and Cells"
DOI: 10.14348/molcells.2023.2191
Abstract: The oxidative balance of a cell is maintained by the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway. This cytoprotective pathway detoxifies reactive oxygen species and xenobiotics. The role of the… read more here.
Keywords: keap1 nrf2; multi faceted; nrf2 activation; faceted consequences ... See more keywords
β-Arrestin1 Reduces Oxidative Stress via Nrf2 Activation in the Rostral Ventrolateral Medulla in Hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.657825
Abstract: Oxidative stress in the rostral ventrolateral medulla (RVLM), a key region for blood pressure (BP) regulation, has been demonstrated to be responsible for the overactivity of the sympathetic nervous system in hypertension and heart failure.… read more here.
Keywords: stress; arrestin1; nrf2 activation; rvlm ... See more keywords