Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Trauma and Emergency Surgery"
DOI: 10.1007/s00068-019-01216-z
Abstract: Purpose The purpose of this study was to investigate the effects of bardoxolone methyl (BM), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator, on acute kidney injury in a rat model of crush syndrome… read more here.
Keywords: nrf2 activator; kidney injury; crush; crush related ... See more keywords
Neuroprotective effect of an Nrf2‐ARE activator identified from a chemical library on dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.11.023
Abstract: Abstract The nuclear factor erythroid 2‐related factor 2 (Nrf2)‐antioxidant response element (ARE) pathway, which induces the production of antioxidant enzymes, is a possible therapeutic target for treating diseases related to oxidative stress. Nrf2 activators often… read more here.
Keywords: chemical library; nrf2 activator; identified chemical; effect ... See more keywords
Ketone body 3‐hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina
Sign Up to like & getrecommendations! Published in 2018 at "Aging Cell"
DOI: 10.1111/acel.12699
Abstract: Calorie restriction (CR) being the most robust dietary intervention provides various health benefits. D‐3‐hydroxybutyrate (3HB), a major physiological ketone, has been proposed as an important endogenous molecule for CR. To investigate the role of 3HB… read more here.
Keywords: nrf2 activator; activator fumarate; calorie restriction; ketone ... See more keywords
The Novel Nrf2 Activator Omaveloxolone Regulates Microglia Phenotype and Ameliorates Secondary Brain Injury after Intracerebral Hemorrhage in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4564471
Abstract: The polarization of microglia is recognized as a crucial factor in reducing neuroinflammation and promoting hematoma clearance after intracerebral hemorrhage (ICH). Previous studies have revealed that redox components participate in the regulation of microglial polarization.… read more here.
Keywords: nrf2 activator; activator omaveloxolone; novel nrf2; intracerebral hemorrhage ... See more keywords
Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy
Sign Up to like & getrecommendations! Published in 2021 at "Therapeutic Advances in Respiratory Disease"
DOI: 10.1177/1753466621998245
Abstract: Inhalable nanostructured microparticles of simvastatin, a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor, were rationally designed for targeted pulmonary delivery as dry powder inhalers (DPIs) for the treatment of pulmonary hypertension (PH). Advanced particle engineering… read more here.
Keywords: nrf2 activator; microscopy; activator rhoa; spectroscopy ... See more keywords