The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo
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DOI: 10.1128/mcb.00563-21
Abstract: Nrf2 activates cytoprotective gene expression, and Nrf2 activity is regulated through at least two protein degradation pathways: the Keap1-mediated and β-TrCP-mediated pathways. To address the relative contributions of these pathways, we generated knock-in mouse lines… read more here.
Keywords: mediated pathway; trcp mediated; keap1 mediated; nrf2 activity ... See more keywords
Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury
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DOI: 10.3390/antiox11091810
Abstract: Acute kidney injury (AKI) is a rapid decline in renal function and can occur after ischemia/reperfusion injury (IRI) to the tubular epithelia. The nuclear factor erythroid-2-related factor 2 (NRF2) pathway protects against AKI and AKI-to-chronic… read more here.
Keywords: acute kidney; iri; activity; injury ... See more keywords