Genetic, metabolic and immunological features of cancers with NRF2 addiction
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14458
Abstract: Nuclear factor erythroid‐derived 2‐like 2 (NRF2) is a master transcription factor that coordinately regulates the expression of many cytoprotective genes and plays a central role in defense mechanisms against oxidative and electrophilic insults. Although increased… read more here.
Keywords: cancer cells; metabolic immunological; nrf2 addiction; genetic metabolic ... See more keywords
IL-11 Contribution to Tumorigenesis in an NRF2 Addiction Cancer Model
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.143
Abstract: The KEAP1-NRF2 system, originally identified as a critical defense mechanism against oxidative stress, is often dysregulated in various human cancers forming solid tumors, resulting in the aberrant activation of NRF2. Increased accumulation of NRF2 in… read more here.
Keywords: cancer; tumorigenesis; cancer model; nrf2 addiction ... See more keywords
NRF2 addiction in cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13537
Abstract: The Kelch‐like ECH‐associated protein 1/nuclear factor erythroid‐derived 2‐like 2 (KEAP1‐NRF2) system is a pivotal defense mechanism against oxidative and electrophilic stress. Although transient NRF2 activation in response to stress is beneficial for health, persistent NRF2… read more here.
Keywords: addicted cancers; nrf2 addicted; cells nrf2; nrf2 addiction ... See more keywords