The Bcl‐2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28091
Abstract: Induction of reactive oxygen species (ROS), an important process for the cytotoxicity of various acute myeloid leukemia (AML) therapies including hypomethylating agents (HMAs), concurrently activates the NF‐E2‐related factor 2 (Nrf2) antioxidant response pathway which in… read more here.
Keywords: venetoclax; nrf2 antioxidant; treatment; hypomethylating agents ... See more keywords
Panax notoginseng saponins suppress lipopolysaccharide‐induced barrier disruption and monocyte adhesion on bEnd.3 cells via the opposite modulation of Nrf2 antioxidant and NF‐κB inflammatory pathways
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6488
Abstract: Dysfunction of the blood‐brain barrier (BBB) is a prerequisite for the pathogenesis of many cerebral diseases. Oxidative stress and inflammation are well‐known factors accounting for BBB injury. Panax notoginseng saponins (PNS), a clinical commonly used… read more here.
Keywords: notoginseng saponins; panax notoginseng; nrf2 antioxidant; adhesion bend ... See more keywords
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-020-09581-7
Abstract: Doxorubicin (DOX) is a widely prescribed anthracycline antineoplastic drug for treating human solid tumors and leukemias. However, DOX therapy is limited by a cumulative, dose-dependent, and irreversible cardiomyopathy that occurs with repeated administration. Presumably, a… read more here.
Keywords: response system; antioxidant response; keap1 nrf2; response ... See more keywords
MicroRNA-152-3p protects neurons from oxygen-glucose-deprivation/reoxygenation-induced injury through upregulation of Nrf2/ARE antioxidant signaling by targeting PSD-93.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.012
Abstract: MicroRNAs (miRNAs) have emerged as critical regulators of ischemic stroke, a condition that affects neuronal survival. However, the precise role of miRNAs in regulating neuronal injury during ischemic stroke remains largely unknown. In this study,… read more here.
Keywords: ischemic stroke; nrf2 antioxidant; glucose deprivation; antioxidant signaling ... See more keywords
TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111988
Abstract: Tripartite motif 16 (TRIM16) has emerged as a novel oxidative stress-responsive protein that confers cytoprotective effects by reinforcing the cellular antioxidant system. However, whether TRIM16 is involved in regulating oxidative stress during cerebral ischemia/reperfusion injury… read more here.
Keywords: ogd induced; nrf2 antioxidant; downregulation; trim16 ... See more keywords
A MXene-derived redox homeostasis regulator perturbs the Nrf2 antioxidant program for reinforced sonodynamic therapy
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc07073h
Abstract: Ultrasound (US)-mediated sonodynamic therapy (SDT) has emerged as a spatiotemporally controllable therapeutic modality in combating cancer because of its high tissue-penetration depth and minimal invasiveness. However, the elevated nuclear factor erythroid 2-related factor 2 (Nrf2)… read more here.
Keywords: antioxidant program; mxene derived; sonodynamic therapy; nrf2 antioxidant ... See more keywords
C60 Fullerene Prevents Restraint Stress-Induced Oxidative Disorders in Rat Tissues: Possible Involvement of the Nrf2/ARE-Antioxidant Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/2518676
Abstract: The effects of C60FAS (50 and 500 μg/kg) supplementation, in a normal physiological state and after restraint stress exposure, on prooxidant/antioxidant balance in rat tissues were explored and compared with the effects of the known exogenous… read more here.
Keywords: protein; nrf2 antioxidant; rat tissues; antioxidant pathway ... See more keywords
α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0226769
Abstract: The production of reactive oxygen species (ROS) by cisplatin is one of the major mechanisms of cisplatin-induced cytotoxicity. We examined the preventive effect of α-lipoic acid (LA) on cisplatin-induced toxicity via its antioxidant effects on… read more here.
Keywords: antioxidant activity; nrf2 antioxidant; cisplatin; activation nrf2 ... See more keywords
Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2023.1102146
Abstract: Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway is an important… read more here.
Keywords: promoting effects; antioxidant pathway; health; nrf2 antioxidant ... See more keywords
Up-Regulation of the Nrf2/HO-1 Antioxidant Pathway in Macrophages by an Extract from a New Halophilic Archaea Isolated in Odiel Saltworks
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12051080
Abstract: The production of reactive oxygen species (ROS) plays an important role in the progression of many inflammatory diseases. The search for antioxidants with the ability for scavenging free radicals from the body cells that reduce… read more here.
Keywords: antioxidant pathway; odiel saltworks; nrf2 antioxidant; isolated odiel ... See more keywords
Nrf2 and Antioxidant Response in Animal Models of Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043082
Abstract: This perspective examines the proposition that chronically elevated blood glucose levels caused by type 2 diabetes (T2D) harm body tissues by locally generating reactive oxygen species (ROS). A feed-forward scenario is described in which the… read more here.
Keywords: antioxidant response; beta; nrf2 antioxidant; type diabetes ... See more keywords