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   Articles with "nrf2 axis" as a keyword



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KEAP1/NRF2 axis regulates H2O2-induced apoptosis of pancreatic β-cells.

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recommendations! Published in 2019 at "Gene"

DOI: 10.1016/j.gene.2018.11.100

Abstract: In human pancreatic β-cells, oxidative stress and cellular injures can be induced by H2O2 treatment. The KEAP1/NRF2 axis is a key antioxidant signaling pathway. The present study attempted to elucidate the mechanism by which the… read more here.

Keywords: nrf2 axis; induced apoptosis; pancreatic cells; keap1 nrf2 ... See more keywords
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Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs

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recommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2018/2492063

Abstract: Oxidative and electrophilic changes in cells are mainly coordinated by the KEAP1/NRF2 (Kelch-like erythroid-derived cap-n-collar homology- (ECH-) associated protein-1/nuclear factor (erythroid-derived 2)-like 2) axis. The physical interaction between these two proteins promotes the expression of… read more here.

Keywords: nrf2 axis; methylation; solid tumors; keap1 nrf2 ... See more keywords
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Chrysophanol prevents IL-1β-Induced inflammation and ECM degradation in Osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis.

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recommendations! Published in 2022 at "Biochemical pharmacology"

DOI: 10.2139/ssrn.4217537

Abstract: Osteoarthritis (OA) is a common joint illness that negatively impacts people's lives. The main active ingredient of cassia seed or rhubarb is chrysophanol. It has various pharmacological effects including anticancer, anti-diabetes and blood lipid regulation.… read more here.

Keywords: nrf2 axis; osteoarthritis; sirt6 nrf2; chrysophanol ... See more keywords
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Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.745111

Abstract: NRF2 is an important regulatory transcription factor involved in tumor immunity and tumorigenesis. In this study, we firstly identified that FKBP4/NR3C1 axis was a novel negative regulator of NRF2 in human breast cancer (BC) cells.… read more here.

Keywords: nrf2 axis; proliferation; differentiation maturation; fkbp4 nr3c1 ... See more keywords