Targeting IDH1-Mutated Malignancies with NRF2 Blockade.
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DOI: 10.1093/jnci/djy230
Abstract: Background Neomorphic IDH1 mutations disrupt the redox balance by promoting reactive oxygen species (ROS) production. However, the mechanism by which IDH1-mutant cells maintain ROS homeostasis remains elusive. It is also not known whether reprogrammed ROS… read more here.
Keywords: nrf2 blockade; mutated cells; idh1 mutated; idh1 ... See more keywords