Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation
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DOI: 10.1007/s11357-018-0047-6
Abstract: Aging-induced pro-inflammatory phenotypic alterations of the cerebral vasculature critically contribute to the pathogenesis of vascular cognitive impairment. Cellular senescence is a fundamental aging process that promotes inflammation; however, its role in cerebrovascular aging remains unexplored.… read more here.
Keywords: age related; senescence; inflammation; nrf2 deficiency ... See more keywords
Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice
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DOI: 10.1093/cvr/cvy143
Abstract: Aims Oxidative stress and inflammation play an important role in the progression of atherosclerosis. Transcription factor NF-E2-related factor 2 (Nrf2) has antioxidant and anti-inflammatory effects in the vessel wall, but paradoxically, global loss of Nrf2… read more here.
Keywords: ldlr apob100; apob100 100; nrf2 deficiency; mice ... See more keywords
NRF2 deficiency increases obesity susceptibility in a mouse menopausal model
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DOI: 10.1371/journal.pone.0228559
Abstract: The risk of metabolic abnormalities in menopausal women increases significantly due to the decline in estrogen level. Nuclear factor E2-related factor 2 (NRF2) is an important oxidative stress sensor that plays regulatory role in energy… read more here.
Keywords: deficiency; nrf2 deficiency; menopausal model; level ... See more keywords
Nrf2 deficiency causes hepatocyte dedifferentiation and reduced albumin production in an experimental extrahepatic cholestasis model
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DOI: 10.1371/journal.pone.0269383
Abstract: The transcription factor Nrf2 modulates the initiation and progression of a number of diseases including liver disorders. We evaluated whether Nrf2 mediates hepatic adaptive responses to cholestasis. Wild-type and Nrf2-null mice were subjected to bile… read more here.
Keywords: cholestasis; nrf2 deficiency; expression; albumin production ... See more keywords