Does JNK Regulate Acetaminophen Hepatotoxicity by Modulating Nrf2-dependent Genes or Mitochondrial Oxidant Stress?
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31442
Abstract: We read with interest the recent paper by Chen and coworkers who provided evidence for Nrf2 as a novel target for c-jun N-terminal kinase (JNK).1 Although we agree that JNK activation is a critical part… read more here.
Keywords: nrf2 dependent; jnk; regulate acetaminophen; hepatotoxicity ... See more keywords
Vitamin D protects against particles‐caused lung injury through induction of autophagy in an Nrf2‐dependent manner
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22726
Abstract: Fine particulate matter is a well‐known air pollutant threatening public health. Studies have confirmed long‐term exposure to the particles could decrease the pulmonary function, induce asthma exacerbation, and chronic obstructive pulmonary disease, as well as… read more here.
Keywords: nrf2 dependent; autophagy nrf2; induced pulmonary; induction autophagy ... See more keywords
Hirudin protects against isoproternol-induced myocardial infraction by alleviating oxidative via an Nrf2 dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.06.097
Abstract: Oxidative stress plays a critical role in the progression of myocardial injury. Increasing evidence suggests that hiruidin can treat patients with cardio-injury. However, the mechanism of hirudin against myocardial infraction remains unknown. In the present… read more here.
Keywords: nrf2 dependent; protects isoproternol; myocardial infraction; infraction ... See more keywords
PM2.5 Increases Systemic Inflammatory Cells and Associated Disease Risks by Inducing NRF2-Dependent Myeloid-Biased Hematopoiesis in Adult Male Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c09024
Abstract: Although PM2.5 (fine particles with aerodynamic diameter read more here.
Keywords: biased hematopoiesis; disease risks; hematopoiesis; pm2 ... See more keywords
Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins
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DOI: 10.1155/2017/6785852
Abstract: We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on Nrf2-mediated anti-inflammatory responses have not been elucidated yet.… read more here.
Keywords: hyperglycemic stress; nrf2 dependent; inhibitor; aldose reductase ... See more keywords
Abstract PR16: A druggable transcriptional vulnerability in NRF2-dependent lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.synthleth-pr16
Abstract: The b-ZIP transcription factor NRF2 is a master regulator of the cellular antioxidant response and frequently activated in Non-Small Cell Lung Cancers (NSCLCs). While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant activation… read more here.
Keywords: vulnerability nrf2; nrf2 dependent; druggable transcriptional; lung ... See more keywords
Coptisine attenuates post‑infectious IBS via Nrf2‑dependent inhibition of the NLPR3 inflammasome.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular medicine reports"
DOI: 10.3892/mmr.2022.12879
Abstract: Inhibition of the activation of the NLR family pyrin domain‑containing 3 (NLRP3) inflammasome has previously been reported to confer protection against post‑infectious irritable bowel syndrome (PI‑IBS). Coptisine, the second most abundant isoquinoline alkaloid in Coptis chinensis,… read more here.
Keywords: dependent inhibition; via nrf2; inhibition; post infectious ... See more keywords