Nrf2 activator corosolic acid meliorates alloxan induced diabetic nephropathy in mice
Sign Up to like & getrecommendations! Published in 2017 at "Asian pacific Journal of Tropical Biomedicine"
DOI: 10.1016/j.apjtb.2017.08.010
Abstract: Abstract Objective To determine whether corosolic acid (CA) targeting nuclear protein expression of Nrf2 activation can be used to attenuate renal damage and preserve renal function in alloxan diabetic mice. Methods A mouse model with… read more here.
Keywords: nrf2 expression; corosolic acid; diabetic nephropathy; mice ... See more keywords
High glucose concentrations induce oxidative stress by inhibiting Nrf2 expression in rat Müller retinal cells in vitro.
Sign Up to like & getrecommendations! Published in 2022 at "Scientific reports"
DOI: 10.1038/s41598-022-05284-x
Abstract: Diabetic retinopathy (DR) is a complication of diabetes. Several studies have implicated oxidative stress as a fundamental factor in the progression of the disease. The nuclear factor erythroid-2-related factor 2 (Nrf2) is one of the… read more here.
Keywords: oxidative stress; glucose concentrations; high glucose; nrf2 expression ... See more keywords
High-Salt Loading Downregulates Nrf2 Expression in a Sodium-Dependent Manner in Renal Collecting Duct Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.01565
Abstract: Background High salt intake is associated with both oxidative stress and chronic kidney disease (CKD) progression. Nuclear factor E2-related factor 2 (Nrf2) is a transcriptional factor regulating the antioxidant and detoxifying genes to potently antagonize… read more here.
Keywords: salt; salt loading; sodium; nrf2 expression ... See more keywords
Salidroside protects the cardiac function of exhausted rats by inducing Nrf2 expression.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular journal of Africa"
DOI: 10.5830/cvja-2019-043
Abstract: OBJECTIVE To investigate whether salidroside (Sal) protected the rat heart from exhaustive exercise-induced injury by inducing nuclear factor erythroid 2-related factor 2 (Nrf2) expression. METHODS Forty-eight male Sprague-Dawley rats were divided into four groups (n… read more here.
Keywords: cardiac function; sal; group; nrf2 expression ... See more keywords