The Nrf2‐GPX4 Pathway Provides Protection Against Rheumatoid Arthritis via Inhibition of Macrophage Ferroptosis‐Mediated Inflammation and Synovial Fibroblast Proliferation
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DOI: 10.1002/jbt.70539
Abstract: Abnormal activation and proliferation of rheumatoid arthritis synovial fibroblasts (RASFs) play an important role in rheumatoid arthritis (RA), the mechanism of which remains elusive. The purpose of our study is to comprehensively explore the mechanism… read more here.
Keywords: proliferation; macrophage ferroptosis; nrf2 gpx4; arthritis ... See more keywords
Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferroptosis in Hippocampal Neurons Via Activating the Nrf2/GPX4/SLC7A11 Pathway
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DOI: 10.1007/s11481-024-10167-1
Abstract: Post-stroke depression (PSD) poses a serious impact on patients’ life quality. Effective drugs to treat this annoying disease are still being sought. Yi-nao-jie-yu (YNJY) prescription has been found to relieve PSD; however, the underlying mechanisms… read more here.
Keywords: nrf2 gpx4; ynjy prescription; damage; ferroptosis ... See more keywords
Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway
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DOI: 10.1016/j.brainresbull.2022.02.018
Abstract: BACKGROUND Autism spectrum disorder (ASD) is a group of extensive neurodevelopmental disorders for which few efficacious drugs are available. Sodium selenite (Se), the most common inorganic form of selenium given to humans and animals, has… read more here.
Keywords: ferroptosis; nrf2 gpx4; btbr mice; gpx4 pathway ... See more keywords
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2023.2165114
Abstract: Abstract Context Guilu-Erxian-Glue (GLEXG) is a traditional Chinese formula used to improve male reproductive dysfunction. Objective To investigate the ferroptosis resistance of GLEXG in the improvement of semen quality in the oligoasthenospermia (OAS) rat model.… read more here.
Keywords: nrf2 gpx4; histopathology; keap1 nrf2; gpx4 ... See more keywords
USF2 exacerbates sepsis-induced acute kidney injury and ferroptosis through LPCAT3-mediated NRF2/HO-1/GPX4 pathway.
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DOI: 10.1097/shk.0000000000002588
Abstract: ABSTRACT Background: Sepsis-acute kidney injury (AKI) is a common complication in critically ill patients with a very high mortality rate. Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is crucial in lipid metabolism; however, its role in the pathogenesis… read more here.
Keywords: sepsis aki; lpcat3; nrf2 gpx4; hk2 cells ... See more keywords
Theaflavin-3,3′-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis
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DOI: 10.1155/2022/3531995
Abstract: There is evidence that osteoarthritis (OA) is associated with ferroptosis which is a kind of lipid peroxidation-related cell death. Theaflavin-3,3′-digallate(TF3), a polyphenol compound extracted from black tea, possesses antioxidative and anti-inflammatory properties, but its effects… read more here.
Keywords: nrf2 gpx4; signaling pathway; gpx4 signaling; gpx4 ... See more keywords
Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway
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DOI: 10.1155/2024/6802701
Abstract: Objective. Ferroptosis, a form of programmed cell death, is considered a novel target for the treatment of ulcerative colitis (UC). The aim of this study was to explore whether modified Gegen Qinlian decoction (MGQD) ameliorates… read more here.
Keywords: mice; gpx4 pathway; nrf2 gpx4; ferroptosis ... See more keywords
Abstract 4459: Metabolic liabilities of iron-dependent ferroptosis mediated through NRF2/GPX4 axis in osteosarcoma
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DOI: 10.1158/1538-7445.am2024-4459
Abstract: Osteosarcoma is an aggressive bone malignancy that predominantly affects adolescents and young adults. Despite recent advancements in treatments, the challenges of recurrence and chemoresistance persist. Ferroptosis is a form of regulated cell death driven by… read more here.
Keywords: nrf2 gpx4; osteosarcoma; iron; ferroptosis ... See more keywords
Activation of the Nrf2/GPX4 Signaling by Pratensein From Trifolium pretense Mitigates Ferroptosis in OGD/R-Insulted H9c2 Cardiomyocytes
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DOI: 10.1177/1934578x221115313
Abstract: Background: Pratensein (PTS) is a type of flavonoid that has been identified in various plants, such as Trifolium pretense L., with a considerable cytoprotective effect against exogenous stimuli. However, the biological function of PTS in… read more here.
Keywords: nrf2 gpx4; gpx4 signaling; h9c2 cells; h9c2 ... See more keywords
Carnosic acid alleviated periodontitis by inhibiting ferroptosis via the Nrf2/GPX4 pathway
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DOI: 10.1186/s12903-025-07048-1
Abstract: Ferroptosis, caused by abnormal iron metabolism and lipid peroxidation, has been linked to pathogenic processes in several disorders. Its function and regulating mechanisms in periodontitis are still unclear, nevertheless. As a naturally derived phenolic diterpenoid… read more here.
Keywords: carnosic acid; nrf2 gpx4; periodontitis; pharmacology ... See more keywords
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
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DOI: 10.1186/s12974-022-02400-6
Abstract: Background The inflammation and oxidative stress (OS) have been considered crucial components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger, processes strong biological activities including antioxidant, anti-inflammatory and neuroprotective properties. However, its… read more here.
Keywords: nrf2 gpx4; sirt1 nrf2; anxiety like; depressive anxiety ... See more keywords