Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2022.02.018
Abstract: BACKGROUND Autism spectrum disorder (ASD) is a group of extensive neurodevelopmental disorders for which few efficacious drugs are available. Sodium selenite (Se), the most common inorganic form of selenium given to humans and animals, has… read more here.
Keywords: ferroptosis; nrf2 gpx4; btbr mice; gpx4 pathway ... See more keywords
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2023.2165114
Abstract: Abstract Context Guilu-Erxian-Glue (GLEXG) is a traditional Chinese formula used to improve male reproductive dysfunction. Objective To investigate the ferroptosis resistance of GLEXG in the improvement of semen quality in the oligoasthenospermia (OAS) rat model.… read more here.
Keywords: nrf2 gpx4; histopathology; keap1 nrf2; gpx4 ... See more keywords
Theaflavin-3,3′-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis
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DOI: 10.1155/2022/3531995
Abstract: There is evidence that osteoarthritis (OA) is associated with ferroptosis which is a kind of lipid peroxidation-related cell death. Theaflavin-3,3′-digallate(TF3), a polyphenol compound extracted from black tea, possesses antioxidative and anti-inflammatory properties, but its effects… read more here.
Keywords: nrf2 gpx4; signaling pathway; gpx4 signaling; gpx4 ... See more keywords
Activation of the Nrf2/GPX4 Signaling by Pratensein From Trifolium pretense Mitigates Ferroptosis in OGD/R-Insulted H9c2 Cardiomyocytes
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DOI: 10.1177/1934578x221115313
Abstract: Background: Pratensein (PTS) is a type of flavonoid that has been identified in various plants, such as Trifolium pretense L., with a considerable cytoprotective effect against exogenous stimuli. However, the biological function of PTS in… read more here.
Keywords: nrf2 gpx4; gpx4 signaling; h9c2 cells; h9c2 ... See more keywords
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway
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DOI: 10.1186/s12974-022-02400-6
Abstract: Background The inflammation and oxidative stress (OS) have been considered crucial components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger, processes strong biological activities including antioxidant, anti-inflammatory and neuroprotective properties. However, its… read more here.
Keywords: nrf2 gpx4; sirt1 nrf2; anxiety like; depressive anxiety ... See more keywords
Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation
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DOI: 10.7150/ijbs.69714
Abstract: Ferroptosis and neuroinflammation play crucial roles in Alzheimer's disease (AD) pathophysiology. Forsythoside A (FA), the main constituent of Forsythia suspensa (Thunb.) Vahl., possesses anti-inflammatory, antibacterial, antioxidant, and neuroprotective properties. The present study aimed to investigate… read more here.
Keywords: nrf2 gpx4; neuroinflammation; pathology; gpx4 axis ... See more keywords