Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease
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DOI: 10.3390/antiox11020247
Abstract: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. It is characterized by a complex network of physiopathological events where oxidative stress plays a central role among other factors such as neuroinflammation and protein… read more here.
Keywords: disease; parkinson disease; inducers selective; dual nrf2 ... See more keywords
NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers
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DOI: 10.3390/antiox11050870
Abstract: Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial regulators of the inflammatory response through the activation of Caspase-1 and induction of pro-inflammatory cytokines and… read more here.
Keywords: pyroptosis; inflammasome pyroptosis; nrf2 inducers; liver pathophysiology ... See more keywords