NGF protects neuroblastoma cells against β‐amyloid‐induced apoptosis via the Nrf2/HO‐1 pathway
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DOI: 10.1002/2211-5463.12742
Abstract: As one of the main neurotrophic factors, nerve growth factor (NGF) participates in various processes related to viability, plasticity, and neuronal growth. NGF is known to protect against cell death and toxicity triggered by β‐amyloid… read more here.
Keywords: protects neuroblastoma; ngf protects; apoptosis; jnk jun ... See more keywords
Ribisins and Certain Analogues Exert Neuroprotective Effects through Activation of the Keap1‐Nrf2‐ARE Pathway
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DOI: 10.1002/cmdc.202200292
Abstract: Oxidative stress contributes to the pathogenesis of various neurodegenerative diseases and induction of the Kelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway is a validated neuroprotective strategy. Synthetically‐derived samples of members… read more here.
Keywords: exert neuroprotective; ribisins certain; factor; nrf2 pathway ... See more keywords
Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway
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DOI: 10.1002/jbt.70158
Abstract: Lycopene (LYC) is an extremely powerful antioxidant with the potential to treat a range of diseases and to inhibit ferroptosis. This research aims to elucidate how LYC impacts polycystic ovarian syndrome (PCOS) and the action… read more here.
Keywords: ampk nrf2; ferroptosis; pcos; nrf2 pathway ... See more keywords
Syringaldehyde Mitigates Cyclophosphamide‐Induced Liver and Kidney Toxicity in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis Through Modulation of the Nrf2/HO‐1/NFκB Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70172
Abstract: Cyclophosphamide (CYC) is one of the most potent antineoplastic drugs; however, hepatonephrotoxicity, observed following its use, remains one of its most severe side effects. Previous studies have reported that syringaldehyde (SYA), a flavonoid compound, exhibits… read more here.
Keywords: nrf2 pathway; hepatonephrotoxicity; oxidative stress; liver kidney ... See more keywords
LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO‐1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27739
Abstract: LL202, a newly synthesized flavonoid derivative, has been confirmed to inhibit the mitogen‐activated protein kinase pathway and activation protein‐1 activation in monocytes; however, the anti‐inflammatory mechanism has not been clearly studied. Uncontrolled overproduction of reactive… read more here.
Keywords: ll202; nrf2 pathway; activation; oxidative stress ... See more keywords
MCFA alleviate H2 O2 -induced oxidative stress in AML12 cells via the ERK1/2/Nrf2 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Lipids"
DOI: 10.1002/lipd.12339
Abstract: Oxidative stress is an important factor in the occurrence and development of liver disease. Medium-chain fatty acids (MCFAs) have potential antioxidant function, whereas the exact underlying mechanism of MCFA in oxidative injury of hepatocytes remains… read more here.
Keywords: stress; oxidative stress; aml12 cells; erk1 nrf2 ... See more keywords
Insight into the regulation of the Nrf2 pathway in response to ascovirus infection in Spodoptera exigua.
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DOI: 10.1002/ps.7284
Abstract: BACKGROUND Ascoviruses are a kind of entomopathogenic microorganisms with high biological pest control potential, which is expected to contribute in natural control of lepidopteran pests. However, knowledge of the molecular mechanism underlying the biocidal activity… read more here.
Keywords: spodoptera exigua; ascovirus; ascovirus infection; nrf2 pathway ... See more keywords
Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway
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DOI: 10.1002/ptr.8294
Abstract: Spinal cord injury (SCI) is a severe disabling disease that is characterized by inflammation and oxidative reactions. Tangeretin has been shown to possess significant antioxidant and anti‐inflammatory activities. The Keap1/Nrf2 pathway, downstream of the Sesn2… read more here.
Keywords: spinal cord; keap1 nrf2; injury; nrf2 pathway ... See more keywords
NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
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DOI: 10.1002/tox.23796
Abstract: PURPOSE This study identified the function of neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) on bladder cancer (BLCA). METHODS NEDD4L expression in BLCA patients was scrutinized. The function of NEDD4L on the viability, apoptosis,… read more here.
Keywords: p62 keap1; nrf2 pathway; blca; keap1 nrf2 ... See more keywords
Combined exposure to lead and microplastics increased risk of glucose metabolism in mice via the Nrf2/NF‐κB pathway
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DOI: 10.1002/tox.24125
Abstract: The purpose of this study was to explore the effects of combined lead (Pb) and two types of microplastic (MP) (polyvinyl chloride [PVC] and polyethylene [PE]) exposure on glucose metabolism and investigate the role of… read more here.
Keywords: mice; glucose metabolism; factor; metabolism ... See more keywords
Novel methyltransferase G9a inhibitor induces ferroptosis in multiple myeloma through Nrf2/HO-1 pathway
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DOI: 10.1007/s00277-024-05728-6
Abstract: Multiple myeloma (MM) is a common malignant hematologic neoplasm, and the involvement of epigenetic modifications in its development and drug resistance has received widespread attention. Ferroptosis, a new ferroptosis-dependent programmed death mode, is closely associated… read more here.
Keywords: multiple myeloma; novel methyltransferase; induces ferroptosis; ferroptosis ... See more keywords