NGF protects neuroblastoma cells against β‐amyloid‐induced apoptosis via the Nrf2/HO‐1 pathway
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DOI: 10.1002/2211-5463.12742
Abstract: As one of the main neurotrophic factors, nerve growth factor (NGF) participates in various processes related to viability, plasticity, and neuronal growth. NGF is known to protect against cell death and toxicity triggered by β‐amyloid… read more here.
Keywords: protects neuroblastoma; ngf protects; apoptosis; jnk jun ... See more keywords
Ribisins and Certain Analogues Exert Neuroprotective Effects through Activation of the Keap1‐Nrf2‐ARE Pathway
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DOI: 10.1002/cmdc.202200292
Abstract: Oxidative stress contributes to the pathogenesis of various neurodegenerative diseases and induction of the Kelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway is a validated neuroprotective strategy. Synthetically‐derived samples of members… read more here.
Keywords: exert neuroprotective; ribisins certain; factor; nrf2 pathway ... See more keywords
LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO‐1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27739
Abstract: LL202, a newly synthesized flavonoid derivative, has been confirmed to inhibit the mitogen‐activated protein kinase pathway and activation protein‐1 activation in monocytes; however, the anti‐inflammatory mechanism has not been clearly studied. Uncontrolled overproduction of reactive… read more here.
Keywords: ll202; nrf2 pathway; activation; oxidative stress ... See more keywords
MCFA alleviate H2 O2 -induced oxidative stress in AML12 cells via the ERK1/2/Nrf2 pathway.
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DOI: 10.1002/lipd.12339
Abstract: Oxidative stress is an important factor in the occurrence and development of liver disease. Medium-chain fatty acids (MCFAs) have potential antioxidant function, whereas the exact underlying mechanism of MCFA in oxidative injury of hepatocytes remains… read more here.
Keywords: stress; oxidative stress; aml12 cells; erk1 nrf2 ... See more keywords
Insight into the regulation of the Nrf2 pathway in response to ascovirus infection in Spodoptera exigua.
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DOI: 10.1002/ps.7284
Abstract: BACKGROUND Ascoviruses are a kind of entomopathogenic microorganisms with high biological pest control potential, which is expected to contribute in natural control of lepidopteran pests. However, knowledge of the molecular mechanism underlying the biocidal activity… read more here.
Keywords: spodoptera exigua; ascovirus; ascovirus infection; nrf2 pathway ... See more keywords
NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
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DOI: 10.1002/tox.23796
Abstract: PURPOSE This study identified the function of neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) on bladder cancer (BLCA). METHODS NEDD4L expression in BLCA patients was scrutinized. The function of NEDD4L on the viability, apoptosis,… read more here.
Keywords: p62 keap1; nrf2 pathway; blca; keap1 nrf2 ... See more keywords
Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway
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DOI: 10.1007/s00441-018-2877-z
Abstract: Sulforaphane (SFN) has been considered as an indirect antioxidant and potential inducer of the Nrf2-ARE pathway. This study was conducted to investigate the protective role of SFN against oxidative stress in bovine granulosa cells (GCs).… read more here.
Keywords: granulosa cells; nrf2 pathway; group; activation nrf2 ... See more keywords
(+)-Usnic acid modulates the Nrf2-ARE pathway in FaDu hypopharyngeal carcinoma cells
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DOI: 10.1007/s11010-021-04092-7
Abstract: Naturally occurring phytochemicals of different origin and structure, arctigenin, bergenin, usnic acid and xanthohumol, were shown to affect Nrf2 pathway in the context of various diseases, but their effect on this pathway in cancer cells… read more here.
Keywords: nrf2 pathway; usnic acid; fadu hypopharyngeal; carcinoma cells ... See more keywords
Identification of potential andrographolide-based drug candidate against Keap1-Nrf2 pathway through rigorous cheminformatics screening.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular diversity"
DOI: 10.1007/s11030-022-10435-3
Abstract: The Keap1-Nrf2 [Kelch-like ECH-associated protein-1-Nuclear factor erythroid-2-related factor-2] regulatory pathway plays a vital role in the protection of cells by regulating transcription of antioxidant and detoxification genes. Andrographolide (AGP) regulates the Keap1-Nrf2 pathway by inhibiting… read more here.
Keywords: keap1 protein; agp; drug; nrf2 pathway ... See more keywords
Gualou Guizhi Granule Protects Against Oxidative Injury by Activating Nrf2/ARE Pathway in Rats and PC12 Cells
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DOI: 10.1007/s11064-018-2507-x
Abstract: Stroke involves numerous pathophysiological processes and oxidative stress is considered as a main cellular event in its pathogenesis. The nuclear factor erythroid-2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway plays a key role in inducing… read more here.
Keywords: nrf2 pathway; oxidative injury; guizhi granule; gualou guizhi ... See more keywords
Beneficial Role of Some Natural Products to Attenuate the Diabetic Cardiomyopathy Through Nrf2 Pathway in Cell Culture and Animal Models
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DOI: 10.1007/s12012-017-9430-2
Abstract: Diabetic cardiomyopathy, as one of the main cardiac complications in diabetic patients, is identified to connect with oxidative stress that is due to interruption in balance between reactive oxygen species or/and reactive nitrogen species generation… read more here.
Keywords: cardiomyopathy nrf2; natural products; nrf2 pathway; role natural ... See more keywords