Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2/ARE/HO-1, PPARγ and TGF-β1/Smad3 signaling, and amelioration of oxidative stress and inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.09.015
Abstract: Hesperidin is a plant-derived bioflavonoid with promising antitumor efficacy, though the underlying mechanisms of action remain poorly elucidated. Thus, we evaluated the in vivo chemopreventive effect of hesperidin against diethylnitrosamine (DEN)-induced hepatocarcinogenesis. We demonstrated the modulatory… read more here.
Keywords: smad3; smad3 signaling; hesperidin; nrf2 ppar ... See more keywords
Dendrobine alleviates CCl4-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways
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DOI: 10.1186/s13020-025-01241-8
Abstract: Acute liver injury (ALI) represents a critical clinical challenge characterized by rapid degradation of hepatic function, necessitating prompt intervention for improved patient outcomes. Dendrobine (DDB) is the main bioactive component of Dendrobium nobile Lindl. (DNL),… read more here.
Keywords: ppar sod2; sod2; activation; liver injury ... See more keywords
Possible Implication of Nrf2, PPAR-γ and MAPKs Signaling in the Protective Role of Mangiferin against Renal Ischemia/Reperfusion in Rats
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DOI: 10.3390/ph16010006
Abstract: Mangiferin (Mang) is a known glucosylxanthone that has proven its shielding effect against ischemia/reperfusion (Is/R). However, its full underlying mechanistic perspective against renal Is/R induced lesions is not fully revealed. Consequently, the purpose of this… read more here.
Keywords: nrf2 ppar; ischemia reperfusion; possible implication; expression ... See more keywords
Nrf2, NF-κB and PPARβ/δ mRNA Expression Profile in Patients with Coronary Artery Disease
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DOI: 10.5935/abc.20190125
Abstract: Background Oxidative stress and inflammation are present in coronary artery disease (CAD) and are linked to the activation of the transcription nuclear factor kappa B (NF-κB). To attenuate these complications, transcription factors like nuclear factor… read more here.
Keywords: ppar; cad; coronary artery; expression ... See more keywords