KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
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DOI: 10.1002/med.21925
Abstract: The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein… read more here.
Keywords: protein protein; protein interaction; keap1 nrf2; pharmacological properties ... See more keywords
Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-020-02539-y
Abstract: Activation of the transcription factor Nrf2 via the Keap1–Nrf2–ARE signaling system regulates the transcription and subsequent expression of cellular cytoprotective proteins and plays a crucial role in preventing pathological conditions exacerbated by the overproduction of… read more here.
Keywords: protein; protein interaction; keap1 nrf2; nrf2 protein ... See more keywords
Dr. Jekyll and Mr. Hyde: Oxidizable phenol‐generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.06.039
Abstract: Abstract The transcription factor Nrf2 is a master regulator of antioxidant and cytoprotective genes, binding to antioxidant response elements (AREs) in their promoter regions. Due to the therapeutic role of the Nrf2/ARE system in oxidative… read more here.
Keywords: accumulation; nrf2 protein; dtbhq; expression ... See more keywords
Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode
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DOI: 10.1021/acs.jmedchem.2c00457
Abstract: Inhibitors of Kelch-like ECH-associated protein 1 (Keap1) increase the activity of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) by stalling its ubiquitination and degradation. This enhances the expression of genes encoding proteins… read more here.
Keywords: protein protein; phenyl bis; protein interaction; keap1 nrf2 ... See more keywords
Effects of trigonelline inhibition of the Nrf2 transcription factor in vitro on Echinococcus granulosus
Sign Up to like & getrecommendations! Published in 2017 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmx067
Abstract: The aim of this study was to investigate the impact of trigonelline (TRG) on Echinococcus granulosus, and to explore the inhibition impact of nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway on E. granulosus protoscoleces.… read more here.
Keywords: echinococcus granulosus; nrf2 protein; inhibition; factor ... See more keywords