Dexmedetomidine attenuates hypoxia‐induced cardiomyocyte injury by promoting telomere/telomerase activity: Possible involvement of ERK1/2‐Nrf2 signaling pathway
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DOI: 10.1002/cbin.11799
Abstract: Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, possesses cardioprotection against ischemic/hypoxic injury, but the exact mechanism is not fully elucidated. Since telomere/telomerase dysfunction is involved in myocardial ischemic damage, the present study aimed to investigate… read more here.
Keywords: signaling pathway; nrf2 signaling; dex; erk1 nrf2 ... See more keywords
Bisphenol S induces oxidative stress‐mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO‐1 signaling pathway
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DOI: 10.1002/jbt.23273
Abstract: Bisphenol S (BPS) is an environmental endocrine disruptor widely used in industrial production. BPS induces oxidative stress and exhibits male reproductive toxicity in mice, but the mechanisms by which BPS impairs steroid hormone synthesis are… read more here.
Keywords: nrf2 signaling; oxidative stress; testosterone synthesis; synthesis ... See more keywords
MicroRNA‐25 aggravates Aβ1‐42‐induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28861
Abstract: Recently, numerous microRNAs (miRNAs) have been considered as key players in the regulation of neuronal processes. The purpose of the present study is to explore the effect of miR‐25 on hippocampal neuron injury in Alzheimer's… read more here.
Keywords: mir; neuron injury; nrf2 signaling; signaling pathway ... See more keywords
Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29219
Abstract: Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant titer. Toxic insults and many other diseased conditions are mediated through the formation of such condition. Once the redox equilibrium is disrupted,… read more here.
Keywords: protection mechanism; regulatory mechanisms; nrf2 signaling; signaling cellular ... See more keywords
Curcumin Alleviated Lipopolysaccharide-Induced Lung Injury Via Regulating Nrf2-ARE and NF-κB Signaling Pathways in Ducks.
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DOI: 10.1002/jsfa.12027
Abstract: BACKGROUND Under the intensive modern poultry farming system, the lung of duck is one of the main targeted organs for various bacterial and viral infections. Curcumin is a kind of natural polyphenol compound which exist… read more here.
Keywords: lung injury; curcumin; nrf2 signaling; induced lung ... See more keywords
Regulation of Wheat Bran Feruloyl Oligosaccharides in the Intestinal Antioxidative Capacity of Rats Associated with p38/JNK-Nrf2 Signaling Pathway and Gut Microbiota.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12061
Abstract: BACKGROUND Feruloyl oligosaccharides (FOs), the ferulic acid ester of oligosaccharides, may possess the physiological functions of both ferulic acid and oligosaccharides, including antioxidative activity and gut microbiota modulation capacity. The aim of this study was… read more here.
Keywords: capacity rats; antioxidative capacity; microbiota; capacity ... See more keywords
Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride‐induced acute liver injury by activating Nrf2 signaling pathway in mice
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DOI: 10.1002/tox.22616
Abstract: Oxidative stress and inflammatory response are well known to be involved in the pathogenesis of acute liver injury. This study was performed to examine the hepatoprotective effect of ginsenoside Rg1 (Rg1) against CCl4‐induced acute liver… read more here.
Keywords: rg1; acute liver; nrf2 signaling; signaling pathway ... See more keywords
1,3‐Dichloro‐2‐propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes
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DOI: 10.1002/tox.23615
Abstract: 1,3‐Dichloro‐2‐propanol (1,3‐DCP) is a representative chloropropane environmental contaminant with multiple toxicities. Ferroptosis is a novel iron‐dependent form of regulated cell death that is closely associated with the accumulation of lipid peroxides, Fe2+ and reactive oxygen… read more here.
Keywords: signaling pathway; nrf2 signaling; dichloro propanol; induced ferroptosis ... See more keywords
Curcumin confers hepatoprotection against AFB1-induced toxicity via activating autophagy and ameliorating inflammation involving Nrf2/HO-1 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology Reports"
DOI: 10.1007/s11033-018-4323-4
Abstract: The current study demonstrated curcumin intervention against AFB1-indeuced hepatotoxicity. The hallmarks of autophagy and inflammation were assessed by transmission electron microscopy, RT-PCR and western blot. Besides, normal cellular morphology, autophagosomes were found in control and… read more here.
Keywords: involving nrf2; inflammation; inflammation involving; nrf2 signaling ... See more keywords
Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
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DOI: 10.1007/s11356-020-08557-y
Abstract: Chicoric acid (CA) is a natural antioxidant with promising hepatoprotective activity. We investigated the potential of CA to prevent methotrexate (MTX) hepatotoxicity, pointing to the role of Nrf2/HO-1 signaling and PPARγ. Rats received CA for… read more here.
Keywords: ppar; stress inflammation; chicoric acid; nrf2 signaling ... See more keywords
Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2/HO-1 signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-018-1241-7
Abstract: Polydatin is a traditional Chinese medicine that provides myocardial protection after acute myocardial infarction (AMI). The study aim was to investigate the myocardial protection polydatin in H9c2 myocardial cells cultured in a hypoxic atmosphere and… read more here.
Keywords: myocardial infarction; nrf2 signaling; polydatin; damage ... See more keywords